Conserved and variable natural killer cell receptors: diverse approaches to viral infections
Conserved and variable natural killer cell receptors: diverse approaches to viral infections
Natural killer (NK) cells are lymphocytes of the innate immune system with essential roles during viral infections. NK cell functions are mediated through a repertoire of non-rearranging inhibitory and activating receptors that interact with major histocompatibility complex (MHC)–peptide complexes on the surface of infected cells. Recent work studying the conserved CD94–NKG2A and variable killer cell immunoglobulin-like receptor–MHC systems suggest that these two receptor families may have subtly different properties in terms of interactions with MHC class I bound peptides, and in recognition of down-regulation of MHC class I. In this review, we discuss how these properties generate diversity in the NK cell response to viruses.
conserved, natural killer cells, polymorphic, receptor–ligand, viral infection
319-328
Bastidas-Legarda, Leidy Y.
4139bf19-55ec-471a-bb94-b1b14556f996
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
April 2019
Bastidas-Legarda, Leidy Y.
4139bf19-55ec-471a-bb94-b1b14556f996
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Bastidas-Legarda, Leidy Y. and Khakoo, Salim I.
(2019)
Conserved and variable natural killer cell receptors: diverse approaches to viral infections.
Immunology, 156 (4), .
(doi:10.1111/imm.13039).
Abstract
Natural killer (NK) cells are lymphocytes of the innate immune system with essential roles during viral infections. NK cell functions are mediated through a repertoire of non-rearranging inhibitory and activating receptors that interact with major histocompatibility complex (MHC)–peptide complexes on the surface of infected cells. Recent work studying the conserved CD94–NKG2A and variable killer cell immunoglobulin-like receptor–MHC systems suggest that these two receptor families may have subtly different properties in terms of interactions with MHC class I bound peptides, and in recognition of down-regulation of MHC class I. In this review, we discuss how these properties generate diversity in the NK cell response to viruses.
This record has no associated files available for download.
More information
Accepted/In Press date: 12 December 2018
e-pub ahead of print date: 20 December 2018
Published date: April 2019
Keywords:
conserved, natural killer cells, polymorphic, receptor–ligand, viral infection
Identifiers
Local EPrints ID: 429378
URI: http://eprints.soton.ac.uk/id/eprint/429378
ISSN: 0019-2805
PURE UUID: dbe7719b-6fae-4de3-9a58-ecbbe453b3bc
Catalogue record
Date deposited: 26 Mar 2019 17:30
Last modified: 16 Mar 2024 03:25
Export record
Altmetrics
Contributors
Author:
Leidy Y. Bastidas-Legarda
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
