The University of Southampton
University of Southampton Institutional Repository

Conserved and variable natural killer cell receptors: diverse approaches to viral infections

Conserved and variable natural killer cell receptors: diverse approaches to viral infections
Conserved and variable natural killer cell receptors: diverse approaches to viral infections

Natural killer (NK) cells are lymphocytes of the innate immune system with essential roles during viral infections. NK cell functions are mediated through a repertoire of non-rearranging inhibitory and activating receptors that interact with major histocompatibility complex (MHC)–peptide complexes on the surface of infected cells. Recent work studying the conserved CD94–NKG2A and variable killer cell immunoglobulin-like receptor–MHC systems suggest that these two receptor families may have subtly different properties in terms of interactions with MHC class I bound peptides, and in recognition of down-regulation of MHC class I. In this review, we discuss how these properties generate diversity in the NK cell response to viruses.

conserved, natural killer cells, polymorphic, receptor–ligand, viral infection
0019-2805
319-328
Bastidas-Legarda, Leidy Y.
4139bf19-55ec-471a-bb94-b1b14556f996
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Bastidas-Legarda, Leidy Y.
4139bf19-55ec-471a-bb94-b1b14556f996
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Bastidas-Legarda, Leidy Y. and Khakoo, Salim I. (2019) Conserved and variable natural killer cell receptors: diverse approaches to viral infections. Immunology, 156 (4), 319-328. (doi:10.1111/imm.13039).

Record type: Article

Abstract

Natural killer (NK) cells are lymphocytes of the innate immune system with essential roles during viral infections. NK cell functions are mediated through a repertoire of non-rearranging inhibitory and activating receptors that interact with major histocompatibility complex (MHC)–peptide complexes on the surface of infected cells. Recent work studying the conserved CD94–NKG2A and variable killer cell immunoglobulin-like receptor–MHC systems suggest that these two receptor families may have subtly different properties in terms of interactions with MHC class I bound peptides, and in recognition of down-regulation of MHC class I. In this review, we discuss how these properties generate diversity in the NK cell response to viruses.

Full text not available from this repository.

More information

Accepted/In Press date: 12 December 2018
e-pub ahead of print date: 20 December 2018
Published date: April 2019
Keywords: conserved, natural killer cells, polymorphic, receptor–ligand, viral infection

Identifiers

Local EPrints ID: 429378
URI: https://eprints.soton.ac.uk/id/eprint/429378
ISSN: 0019-2805
PURE UUID: dbe7719b-6fae-4de3-9a58-ecbbe453b3bc

Catalogue record

Date deposited: 26 Mar 2019 17:30
Last modified: 26 Mar 2019 17:30

Export record

Altmetrics

Contributors

Author: Leidy Y. Bastidas-Legarda
Author: Salim I. Khakoo

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×