Nocturnal oxygen saturation and painful sickle cell crises in children
Nocturnal oxygen saturation and painful sickle cell crises in children
The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration, and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, laboratory, and sleep study data and frequency of painful crisis was investigated. Both univariate and multiple regression modeling showed that low nocturnal oxygen saturation was highly significantly associated with a higher rate of painful crisis in childhood (P < .0001). Screening and treatment for hypoxemia may reduce the frequency of this and other complications of the disease.
846-848
Hargrave, Darren R.
ffb8f016-db32-44c7-9c66-f05b84431164
Wade, Angie
b16ea563-001c-4457-b866-75121ee8b38b
Evans, Jane P. M.
012f896d-f0c8-40fd-b871-e62bc982e30d
Hewes, Deborah K M
e7ddeb9b-911c-43a3-bac4-2ca9d32027ed
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
1 February 2003
Hargrave, Darren R.
ffb8f016-db32-44c7-9c66-f05b84431164
Wade, Angie
b16ea563-001c-4457-b866-75121ee8b38b
Evans, Jane P. M.
012f896d-f0c8-40fd-b871-e62bc982e30d
Hewes, Deborah K M
e7ddeb9b-911c-43a3-bac4-2ca9d32027ed
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Hargrave, Darren R., Wade, Angie, Evans, Jane P. M., Hewes, Deborah K M and Kirkham, Fenella J.
(2003)
Nocturnal oxygen saturation and painful sickle cell crises in children.
Blood, 101 (3), .
(doi:10.1182/blood-2002-05-1392).
Abstract
The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration, and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, laboratory, and sleep study data and frequency of painful crisis was investigated. Both univariate and multiple regression modeling showed that low nocturnal oxygen saturation was highly significantly associated with a higher rate of painful crisis in childhood (P < .0001). Screening and treatment for hypoxemia may reduce the frequency of this and other complications of the disease.
This record has no associated files available for download.
More information
Published date: 1 February 2003
Identifiers
Local EPrints ID: 429522
URI: http://eprints.soton.ac.uk/id/eprint/429522
ISSN: 0006-4971
PURE UUID: 2e400d74-7a14-4d98-9b6c-a8db232fc4bb
Catalogue record
Date deposited: 28 Mar 2019 17:30
Last modified: 16 Mar 2024 03:22
Export record
Altmetrics
Contributors
Author:
Darren R. Hargrave
Author:
Angie Wade
Author:
Jane P. M. Evans
Author:
Deborah K M Hewes
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
