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A pilot study of evaluation of cerebral function by S100β protein and near-infrared spectroscopy during cold and warm cardiopulmonary bypass in infants and children undergoing open-heart surgery

A pilot study of evaluation of cerebral function by S100β protein and near-infrared spectroscopy during cold and warm cardiopulmonary bypass in infants and children undergoing open-heart surgery
A pilot study of evaluation of cerebral function by S100β protein and near-infrared spectroscopy during cold and warm cardiopulmonary bypass in infants and children undergoing open-heart surgery

Cerebral injury in children undergoing cardiopulmonary bypass (CPB) remains a major source of morbidity. The effect of cardiopulmonary bypass temperature on cerebral function in terms of serum S100β protein level and cerebral oxygenation monitored by near infrared spectroscopy (NIRO-300) in children is not known. In this study, 18 children undergoing open-heart surgery at the Hospital for Sick Children in London were equally assigned by minimisation to warm (35 ± 1 °C) or cold (25 ± 1 °C) CPB. Changes in S100β protein and cerebral oxygenation were studied in both groups. S100β protein serum level increased significantly after CPB in both groups. There was no significant difference in serum S100β protein concentrations between the two groups. However, cerebral oxygenation in terms of tissue oxygen index (TOI) was significantly impaired during rewarming from cold CPB. Five patients were desaturated (TOI < 50%) during rewarming in the cold bypass group compared to two in the warm patients. This study supports the use of warm CPB in children undergoing open-heart surgery, although further studies recruiting more patients are warranted.

Brain function, S100β protein cerebral oxygenation, Cardiopulmonary bypass, cold, warm
0003-2409
20-26
Shaaban Ali, M.
deaf3f30-6f54-46df-a2ce-c7dfe973595d
Harmer, M.
e38c025d-79c5-41c5-a0c8-4e5aaa77ef59
Elliott, M.
72144b37-250f-4bf8-8454-0c17e1318bfa
Lloyd Thomas, A.
91d87681-b32b-408c-b9a2-27449d43e932
Kirkham, F.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Shaaban Ali, M.
deaf3f30-6f54-46df-a2ce-c7dfe973595d
Harmer, M.
e38c025d-79c5-41c5-a0c8-4e5aaa77ef59
Elliott, M.
72144b37-250f-4bf8-8454-0c17e1318bfa
Lloyd Thomas, A.
91d87681-b32b-408c-b9a2-27449d43e932
Kirkham, F.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58

Shaaban Ali, M., Harmer, M., Elliott, M., Lloyd Thomas, A. and Kirkham, F. (2004) A pilot study of evaluation of cerebral function by S100β protein and near-infrared spectroscopy during cold and warm cardiopulmonary bypass in infants and children undergoing open-heart surgery. Anaesthesia, 59 (1), 20-26. (doi:10.1111/j.1365-2044.2004.03578.x).

Record type: Article

Abstract

Cerebral injury in children undergoing cardiopulmonary bypass (CPB) remains a major source of morbidity. The effect of cardiopulmonary bypass temperature on cerebral function in terms of serum S100β protein level and cerebral oxygenation monitored by near infrared spectroscopy (NIRO-300) in children is not known. In this study, 18 children undergoing open-heart surgery at the Hospital for Sick Children in London were equally assigned by minimisation to warm (35 ± 1 °C) or cold (25 ± 1 °C) CPB. Changes in S100β protein and cerebral oxygenation were studied in both groups. S100β protein serum level increased significantly after CPB in both groups. There was no significant difference in serum S100β protein concentrations between the two groups. However, cerebral oxygenation in terms of tissue oxygen index (TOI) was significantly impaired during rewarming from cold CPB. Five patients were desaturated (TOI < 50%) during rewarming in the cold bypass group compared to two in the warm patients. This study supports the use of warm CPB in children undergoing open-heart surgery, although further studies recruiting more patients are warranted.

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More information

Published date: January 2004
Keywords: Brain function, S100β protein cerebral oxygenation, Cardiopulmonary bypass, cold, warm

Identifiers

Local EPrints ID: 429529
URI: http://eprints.soton.ac.uk/id/eprint/429529
ISSN: 0003-2409
PURE UUID: 751dbe88-0c90-4309-8157-d8e22ccdc62d
ORCID for F. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 28 Mar 2019 17:30
Last modified: 16 Mar 2024 03:22

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Contributors

Author: M. Shaaban Ali
Author: M. Harmer
Author: M. Elliott
Author: A. Lloyd Thomas
Author: F. Kirkham ORCID iD

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