Meiotic spindle assembly checkpoint and aneuploidy in males versus females
Meiotic spindle assembly checkpoint and aneuploidy in males versus females
The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.
Aneuploidy, Chiasma, Chromosome segregation, Cohesin, Crossover, Meiosis, Oocyte, Recombination, Spermatocytes
1135-1150
Lane, Simon
8e80111f-5012-4950-a228-dfb8fb9df52d
Kauppi, Liisa
0eb89bfb-5835-4f1f-b36c-8225f55d46e0
March 2019
Lane, Simon
8e80111f-5012-4950-a228-dfb8fb9df52d
Kauppi, Liisa
0eb89bfb-5835-4f1f-b36c-8225f55d46e0
Lane, Simon and Kauppi, Liisa
(2019)
Meiotic spindle assembly checkpoint and aneuploidy in males versus females.
Cellular and Molecular Life Sciences, 76 (6), .
(doi:10.1007/s00018-018-2986-6).
Abstract
The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.
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Lane-Kauppi2019_Article_MeioticSpindleAssemblyCheckpoi
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Accepted/In Press date: 3 December 2018
e-pub ahead of print date: 18 December 2018
Published date: March 2019
Keywords:
Aneuploidy, Chiasma, Chromosome segregation, Cohesin, Crossover, Meiosis, Oocyte, Recombination, Spermatocytes
Identifiers
Local EPrints ID: 429545
URI: http://eprints.soton.ac.uk/id/eprint/429545
ISSN: 1420-682X
PURE UUID: 842e9354-9adc-4367-9015-ff591fa1702a
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Date deposited: 29 Mar 2019 17:30
Last modified: 18 Mar 2024 03:26
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Author:
Simon Lane
Author:
Liisa Kauppi
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