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Meiotic spindle assembly checkpoint and aneuploidy in males versus females

Meiotic spindle assembly checkpoint and aneuploidy in males versus females
Meiotic spindle assembly checkpoint and aneuploidy in males versus females

The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.

Aneuploidy, Chiasma, Chromosome segregation, Cohesin, Crossover, Meiosis, Oocyte, Recombination, Spermatocytes
1420-682X
1135-1150
Lane, Simon
8e80111f-5012-4950-a228-dfb8fb9df52d
Kauppi, Liisa
0eb89bfb-5835-4f1f-b36c-8225f55d46e0
Lane, Simon
8e80111f-5012-4950-a228-dfb8fb9df52d
Kauppi, Liisa
0eb89bfb-5835-4f1f-b36c-8225f55d46e0

Lane, Simon and Kauppi, Liisa (2019) Meiotic spindle assembly checkpoint and aneuploidy in males versus females. Cellular and Molecular Life Sciences, 76 (6), 1135-1150. (doi:10.1007/s00018-018-2986-6).

Record type: Review

Abstract

The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.

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More information

Accepted/In Press date: 3 December 2018
e-pub ahead of print date: 18 December 2018
Published date: March 2019
Keywords: Aneuploidy, Chiasma, Chromosome segregation, Cohesin, Crossover, Meiosis, Oocyte, Recombination, Spermatocytes

Identifiers

Local EPrints ID: 429545
URI: http://eprints.soton.ac.uk/id/eprint/429545
ISSN: 1420-682X
PURE UUID: 842e9354-9adc-4367-9015-ff591fa1702a
ORCID for Simon Lane: ORCID iD orcid.org/0000-0002-8155-0981

Catalogue record

Date deposited: 29 Mar 2019 17:30
Last modified: 25 Feb 2021 02:43

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