Roberts, Graham (2017) Asthma, urticaria and less rare than expected FPIES. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 47 (12), 1510-1511. (doi:10.1111/cea.13059).
Abstract
Recently in the Journal of Allergy and Clinical Immunology, Szefler et al1 have assessed whether once‐daily inhaled tiotropium might improve asthma control in young school‐aged children with severe symptomatic asthma. In a randomized, double‐blind, placebo‐controlled trial of 401 participants, the higher 5 mg dose increased peak FEV1 by 139 mL. While the result is interesting, it is not an outcome measure that a patient would recognize. Unfortunately, as a 12‐week trial, it was probably not long enough to provide data on relevant patient‐orientated outcome measures such as exacerbations or quality of life. Also in Journal of Allergy and Clinical Immunology, Mehr et al2 have provided some population data for the prevalence of food protein‐induced enterocolitis syndrome (FPIES). Using an Australia‐wide survey via the Australian Paediatric Surveillance Unit, where paediatrics notify cases on a monthly basis, 230 infants with FPIES were identified. This gave an incidence of FPIES in Australian infants aged less than 24 months of 15.4/100 000/year. Commoner than expected.
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