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Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow

Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow
Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow

Blood velocities have been measured transcranially, at small Doppler angles, in the middle cerebral artery of normal volunteers. Cerebral blood flow was changed by varying carbon dioxide tension. In four volunteers, the relationships between arterial pCO2 and percentage change in intensity weighted mean, median, and maximum Doppler-shifted frequencies in the internal carotid and middle cerebral arteries were linear with slopes of 2.5 and 2.8% per mm Hg change in pCO2. In 38 volunteers, the relationship between end-expiratory pCO2 and time-averaged maximum Doppler frequency was linear over the range of pCO2 20-60 mm Hg with slopes of 2.5 and 2.9 percentage change per mm Hg, for internal carotid and middle cerebral, respectively. These results are very similar to those reported using direct methods of measuring cerebral blood flow. As the transcranial Doppler method is reproducible, this indicates that changes in middle cerebral blood velocity may be used to monitor changes in flow.

Blood velocity, Cerebral blood flow, Cerebral circulation, End-expiratory/arterial carbon dioxide tension, Pulsed Doppler
0301-5629
15-21
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Padayachee, T.S.
31708c93-2a10-4e77-ab16-ff1178424dd3
Parsons, S.
ab9ace0e-2d62-469d-81cb-95bbab663af3
Seargeant, L.S.
552d288a-9309-47fb-b500-54650eaaab97
House, F.R.
ff018686-ac5f-4a96-9884-3ffeeaa496c9
Gosling, R.G.
5a770b77-41fc-43f2-90fa-f56b9eae30f0
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Padayachee, T.S.
31708c93-2a10-4e77-ab16-ff1178424dd3
Parsons, S.
ab9ace0e-2d62-469d-81cb-95bbab663af3
Seargeant, L.S.
552d288a-9309-47fb-b500-54650eaaab97
House, F.R.
ff018686-ac5f-4a96-9884-3ffeeaa496c9
Gosling, R.G.
5a770b77-41fc-43f2-90fa-f56b9eae30f0

Kirkham, F.J., Padayachee, T.S., Parsons, S., Seargeant, L.S., House, F.R. and Gosling, R.G. (1986) Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow. Ultrasound in Medicine & Biology, 12 (1), 15-21. (doi:10.1016/0301-5629(86)90139-0).

Record type: Article

Abstract

Blood velocities have been measured transcranially, at small Doppler angles, in the middle cerebral artery of normal volunteers. Cerebral blood flow was changed by varying carbon dioxide tension. In four volunteers, the relationships between arterial pCO2 and percentage change in intensity weighted mean, median, and maximum Doppler-shifted frequencies in the internal carotid and middle cerebral arteries were linear with slopes of 2.5 and 2.8% per mm Hg change in pCO2. In 38 volunteers, the relationship between end-expiratory pCO2 and time-averaged maximum Doppler frequency was linear over the range of pCO2 20-60 mm Hg with slopes of 2.5 and 2.9 percentage change per mm Hg, for internal carotid and middle cerebral, respectively. These results are very similar to those reported using direct methods of measuring cerebral blood flow. As the transcranial Doppler method is reproducible, this indicates that changes in middle cerebral blood velocity may be used to monitor changes in flow.

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More information

Published date: January 1986
Keywords: Blood velocity, Cerebral blood flow, Cerebral circulation, End-expiratory/arterial carbon dioxide tension, Pulsed Doppler

Identifiers

Local EPrints ID: 429766
URI: https://eprints.soton.ac.uk/id/eprint/429766
ISSN: 0301-5629
PURE UUID: 0d6b2c50-bb04-47cf-9a09-672fc11814a4
ORCID for F.J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 05 Apr 2019 16:30
Last modified: 13 Jun 2019 00:37

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Contributors

Author: F.J. Kirkham ORCID iD
Author: T.S. Padayachee
Author: S. Parsons
Author: L.S. Seargeant
Author: F.R. House
Author: R.G. Gosling

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