Intracranial pressure in African children with cerebral malaria
Intracranial pressure in African children with cerebral malaria
Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD] 22·6 [7·4] cm CSF, range 10·5-36). Clinical features of our patients suggest that intracranial hypertension is important in the pathogenesis of cerebral malaria in children, especially as a cause of death. We suggest that raised intracranial pressure is secondary to increased cerebral blood volume. Lowering intracranial pressure may significantly reduce the mortality and morbidity of cerebral malaria. The potential risks and benefits of lumbar puncture should be considered carefully in patients with suspected cerebral malaria.
573-576
Newton, C.R.J.C.
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Winstanley, P.A.
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Peshu, N.
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Marsh, K.
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Kirkham, F.J.
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Pasvol, G.
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Warrell, D.A.
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9 March 1991
Newton, C.R.J.C.
492c0d48-d9bd-4e5f-a1fb-1dfdf07f2033
Winstanley, P.A.
755ebebb-a52e-45a4-bbd8-d903fa96f9cd
Peshu, N.
5abe6b16-8d5d-4c0e-b81d-948659635b6f
Marsh, K.
b2950be1-6a47-4677-ad56-bcfa8849f860
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Pasvol, G.
5561ed07-fe85-42f1-b618-1269e4611d97
Warrell, D.A.
096416e7-5ae9-4e8e-b844-eb9ac04a1e75
Newton, C.R.J.C., Winstanley, P.A., Peshu, N., Marsh, K., Kirkham, F.J., Pasvol, G. and Warrell, D.A.
(1991)
Intracranial pressure in African children with cerebral malaria.
The Lancet, 337 (8741), .
(doi:10.1016/0140-6736(91)91638-B).
Abstract
Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD] 22·6 [7·4] cm CSF, range 10·5-36). Clinical features of our patients suggest that intracranial hypertension is important in the pathogenesis of cerebral malaria in children, especially as a cause of death. We suggest that raised intracranial pressure is secondary to increased cerebral blood volume. Lowering intracranial pressure may significantly reduce the mortality and morbidity of cerebral malaria. The potential risks and benefits of lumbar puncture should be considered carefully in patients with suspected cerebral malaria.
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Published date: 9 March 1991
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Local EPrints ID: 429777
URI: http://eprints.soton.ac.uk/id/eprint/429777
ISSN: 0140-6736
PURE UUID: 5a818b95-9681-4249-b4b1-4e0da1b54a71
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Date deposited: 05 Apr 2019 16:30
Last modified: 16 Aug 2024 01:38
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Author:
C.R.J.C. Newton
Author:
P.A. Winstanley
Author:
N. Peshu
Author:
K. Marsh
Author:
G. Pasvol
Author:
D.A. Warrell
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