The University of Southampton
University of Southampton Institutional Repository

Intracranial pressure in African children with cerebral malaria

Intracranial pressure in African children with cerebral malaria
Intracranial pressure in African children with cerebral malaria

Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD] 22·6 [7·4] cm CSF, range 10·5-36). Clinical features of our patients suggest that intracranial hypertension is important in the pathogenesis of cerebral malaria in children, especially as a cause of death. We suggest that raised intracranial pressure is secondary to increased cerebral blood volume. Lowering intracranial pressure may significantly reduce the mortality and morbidity of cerebral malaria. The potential risks and benefits of lumbar puncture should be considered carefully in patients with suspected cerebral malaria.

0140-6736
573-576
Newton, C.R.J.C.
492c0d48-d9bd-4e5f-a1fb-1dfdf07f2033
Winstanley, P.A.
755ebebb-a52e-45a4-bbd8-d903fa96f9cd
Peshu, N.
5abe6b16-8d5d-4c0e-b81d-948659635b6f
Marsh, K.
b2950be1-6a47-4677-ad56-bcfa8849f860
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Pasvol, G.
5561ed07-fe85-42f1-b618-1269e4611d97
Warrell, D.A.
096416e7-5ae9-4e8e-b844-eb9ac04a1e75
Newton, C.R.J.C.
492c0d48-d9bd-4e5f-a1fb-1dfdf07f2033
Winstanley, P.A.
755ebebb-a52e-45a4-bbd8-d903fa96f9cd
Peshu, N.
5abe6b16-8d5d-4c0e-b81d-948659635b6f
Marsh, K.
b2950be1-6a47-4677-ad56-bcfa8849f860
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Pasvol, G.
5561ed07-fe85-42f1-b618-1269e4611d97
Warrell, D.A.
096416e7-5ae9-4e8e-b844-eb9ac04a1e75

Newton, C.R.J.C., Winstanley, P.A., Peshu, N., Marsh, K., Kirkham, F.J., Pasvol, G. and Warrell, D.A. (1991) Intracranial pressure in African children with cerebral malaria. The Lancet, 337 (8741), 573-576. (doi:10.1016/0140-6736(91)91638-B).

Record type: Article

Abstract

Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD] 22·6 [7·4] cm CSF, range 10·5-36). Clinical features of our patients suggest that intracranial hypertension is important in the pathogenesis of cerebral malaria in children, especially as a cause of death. We suggest that raised intracranial pressure is secondary to increased cerebral blood volume. Lowering intracranial pressure may significantly reduce the mortality and morbidity of cerebral malaria. The potential risks and benefits of lumbar puncture should be considered carefully in patients with suspected cerebral malaria.

This record has no associated files available for download.

More information

Published date: 9 March 1991

Identifiers

Local EPrints ID: 429777
URI: http://eprints.soton.ac.uk/id/eprint/429777
ISSN: 0140-6736
PURE UUID: 5a818b95-9681-4249-b4b1-4e0da1b54a71
ORCID for F.J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

Catalogue record

Date deposited: 05 Apr 2019 16:30
Last modified: 23 Jul 2022 01:48

Export record

Altmetrics

Contributors

Author: C.R.J.C. Newton
Author: P.A. Winstanley
Author: N. Peshu
Author: K. Marsh
Author: F.J. Kirkham ORCID iD
Author: G. Pasvol
Author: D.A. Warrell

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×