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Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.

Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.
Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.

1. A method is described for the measurement of phenobarbitone (PB) by reversed phase high performance liquid chromatography (h.p.l.c.) from small samples of whole blood dried onto filter paper strips. 2. The disposition of PB given prophylactically to young children with severe malaria on parenteral quinine is contrasted with that in aparasitaemic Kenyan children on no antimalarial drugs. There were no differences in the disposition of PB between the two groups. 3. Peak blood PB concentrations were equal to or greater than 15 mg l‐1 in 27% of the patients on quinine and 23% of those not on quinine; a concentration of 10 mg l‐1 was achieved or exceeded by 100% and 92% of each group, respectively, and was maintained for 39 +/‐ 24 h (mean +/‐ s.d.), and 33 +/‐ 21 h, respectively. 4. In an open, dose‐finding study, the progress of young children with cerebral malaria given prophylactic PB (10 mg kg‐1), was contrasted with that of controls given no seizure prophylaxis. 5. The drug had no apparent effect on depth or duration of coma, but neither was the incidence of seizures reduced. 6. A controlled trial of prophylactic PB in young children with cerebral malaria is needed, but a larger dose than 10 mg kg‐1 should be studied. 1992 The British Pharmacological Society

0306-5251
149-154
Winstanley, P.A.
755ebebb-a52e-45a4-bbd8-d903fa96f9cd
Newton, C.R.
7ed73682-5c64-4620-b0f9-206198aab42d
Pasvol, G.
5561ed07-fe85-42f1-b618-1269e4611d97
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Mberu, E.
bed848af-92c2-4ac4-b7d0-0935b0189f16
Peshu, N.
5abe6b16-8d5d-4c0e-b81d-948659635b6f
Ward, S.A.
2f35c6e1-bcce-4203-8e17-c2859cb0ef04
Were, J.B.
732f160e-657a-4fae-8859-205cd2b4594f
Warrell, D.A.
f09b274c-62e8-44f8-9583-bec247741f58
Marsh, K.
b2950be1-6a47-4677-ad56-bcfa8849f860
Winstanley, P.A.
755ebebb-a52e-45a4-bbd8-d903fa96f9cd
Newton, C.R.
7ed73682-5c64-4620-b0f9-206198aab42d
Pasvol, G.
5561ed07-fe85-42f1-b618-1269e4611d97
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Mberu, E.
bed848af-92c2-4ac4-b7d0-0935b0189f16
Peshu, N.
5abe6b16-8d5d-4c0e-b81d-948659635b6f
Ward, S.A.
2f35c6e1-bcce-4203-8e17-c2859cb0ef04
Were, J.B.
732f160e-657a-4fae-8859-205cd2b4594f
Warrell, D.A.
f09b274c-62e8-44f8-9583-bec247741f58
Marsh, K.
b2950be1-6a47-4677-ad56-bcfa8849f860

Winstanley, P.A., Newton, C.R., Pasvol, G., Kirkham, F.J., Mberu, E., Peshu, N., Ward, S.A., Were, J.B., Warrell, D.A. and Marsh, K. (1992) Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects. British Journal of Clinical Pharmacology, 33 (2), 149-154. (doi:10.1111/j.1365-2125.1992.tb04017.x).

Record type: Article

Abstract

1. A method is described for the measurement of phenobarbitone (PB) by reversed phase high performance liquid chromatography (h.p.l.c.) from small samples of whole blood dried onto filter paper strips. 2. The disposition of PB given prophylactically to young children with severe malaria on parenteral quinine is contrasted with that in aparasitaemic Kenyan children on no antimalarial drugs. There were no differences in the disposition of PB between the two groups. 3. Peak blood PB concentrations were equal to or greater than 15 mg l‐1 in 27% of the patients on quinine and 23% of those not on quinine; a concentration of 10 mg l‐1 was achieved or exceeded by 100% and 92% of each group, respectively, and was maintained for 39 +/‐ 24 h (mean +/‐ s.d.), and 33 +/‐ 21 h, respectively. 4. In an open, dose‐finding study, the progress of young children with cerebral malaria given prophylactic PB (10 mg kg‐1), was contrasted with that of controls given no seizure prophylaxis. 5. The drug had no apparent effect on depth or duration of coma, but neither was the incidence of seizures reduced. 6. A controlled trial of prophylactic PB in young children with cerebral malaria is needed, but a larger dose than 10 mg kg‐1 should be studied. 1992 The British Pharmacological Society

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Published date: February 1992

Identifiers

Local EPrints ID: 429778
URI: https://eprints.soton.ac.uk/id/eprint/429778
ISSN: 0306-5251
PURE UUID: e0727c30-e4fd-45ec-99bd-78fef0b97051
ORCID for F.J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 05 Apr 2019 16:30
Last modified: 13 Jun 2019 00:37

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Contributors

Author: P.A. Winstanley
Author: C.R. Newton
Author: G. Pasvol
Author: F.J. Kirkham ORCID iD
Author: E. Mberu
Author: N. Peshu
Author: S.A. Ward
Author: J.B. Were
Author: D.A. Warrell
Author: K. Marsh

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