The University of Southampton
University of Southampton Institutional Repository

Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency

Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency
Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency

We have performed localized in vivo proton magnetic resonance spectroscopy on two females with ornithine carbamoyl transferase deficiency during episodes of acute hyperammonemic encephalopathy with focal neurologic abnormalities. Spectra obtained from 2 x 2 x 2 cm cubic volumes at relatively long (135-ms) echo times contain additional signals that are characteristic of glutamine and indicate that glutamine is present in very high concentrations in the brain. The findings are consistent with the hypothesis that intracerebral accumulation of glutamine contributes to the encephalopathy associated with hyperammonemia. In one of the children, spectra obtained after treatment showed a marked decrease in the glutamine signals.

0031-3998
77-81
Connelly, A.
0cb19e67-b09d-458b-8c30-1e9f8a279887
Cross, J.H.
3c10596a-3f6e-418d-9957-8ec0a4e5078c
Gadian, D.G.
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
Hunter, J.V.
00956d6c-542a-49e0-9e4d-711591d89ff6
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Leonard, J.V.
d59675cd-3509-4e9b-9ad8-c7be47c6eea9
Connelly, A.
0cb19e67-b09d-458b-8c30-1e9f8a279887
Cross, J.H.
3c10596a-3f6e-418d-9957-8ec0a4e5078c
Gadian, D.G.
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
Hunter, J.V.
00956d6c-542a-49e0-9e4d-711591d89ff6
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Leonard, J.V.
d59675cd-3509-4e9b-9ad8-c7be47c6eea9

Connelly, A., Cross, J.H., Gadian, D.G., Hunter, J.V., Kirkham, F.J. and Leonard, J.V. (1993) Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency. Pediatric Research, 33 (1), 77-81. (doi:10.1203/00006450-199301000-00016).

Record type: Article

Abstract

We have performed localized in vivo proton magnetic resonance spectroscopy on two females with ornithine carbamoyl transferase deficiency during episodes of acute hyperammonemic encephalopathy with focal neurologic abnormalities. Spectra obtained from 2 x 2 x 2 cm cubic volumes at relatively long (135-ms) echo times contain additional signals that are characteristic of glutamine and indicate that glutamine is present in very high concentrations in the brain. The findings are consistent with the hypothesis that intracerebral accumulation of glutamine contributes to the encephalopathy associated with hyperammonemia. In one of the children, spectra obtained after treatment showed a marked decrease in the glutamine signals.

Full text not available from this repository.

More information

Published date: 1 January 1993

Identifiers

Local EPrints ID: 429780
URI: http://eprints.soton.ac.uk/id/eprint/429780
ISSN: 0031-3998
PURE UUID: 40420244-572c-462d-9694-19409d39b5e0
ORCID for F.J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

Catalogue record

Date deposited: 05 Apr 2019 16:30
Last modified: 13 Jun 2019 00:37

Export record

Altmetrics

Contributors

Author: A. Connelly
Author: J.H. Cross
Author: D.G. Gadian
Author: J.V. Hunter
Author: F.J. Kirkham ORCID iD
Author: J.V. Leonard

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×