H magnetic resonance spectroscopy in the investigation of intractable epilepsy
H magnetic resonance spectroscopy in the investigation of intractable epilepsy
We have been using proton magnetic resonance spectroscopy (1H MRS) in the investigation of adults and children with intractable epilepsy. Spectra were obtained from 2 × 2 times 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N‐acetylaspartate (NAA), creatine+phosphocreatine (Cr), and choline‐containing compounds (Cho). In comparison with control subjects, the epilepsy patients as a group show significant reductions in the NAA signal and in the NAA/Cho + Cr ratio, with increases in the Cho and Cr signals. The reduction in NAA is interpreted in terms of neuronal loss or damage, while the increase in Cr and Cho signals may be a reflection of reactive astrocytosis. 1994 Blackwell Munksgaard
epilepsy, magnetic resonance spectroscopy, temporal lobe.
116-121
Gadian, David
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
Connelly, A.
0cb19e67-b09d-458b-8c30-1e9f8a279887
Duncan, J.S.
493245c5-d7e3-4f54-96db-fbaf3cdbf688
Cross, J.H.
3c10596a-3f6e-418d-9957-8ec0a4e5078c
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Johnson, C.L.
ea4f2e83-eb63-4ea3-8cc2-482ba9faba5d
Vargha‐Khadem, F.
9d4adb9c-2fb3-46c4-9dbb-f3b8052b5036
Nevile, B.G.R.
6e9dfd22-f645-4482-9f01-c82532179433
Jackson, G.D.
1f0399ca-2097-46f8-aed6-88832b4e841b
Gadian, David
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
March 1994
Gadian, David
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
Connelly, A.
0cb19e67-b09d-458b-8c30-1e9f8a279887
Duncan, J.S.
493245c5-d7e3-4f54-96db-fbaf3cdbf688
Cross, J.H.
3c10596a-3f6e-418d-9957-8ec0a4e5078c
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Johnson, C.L.
ea4f2e83-eb63-4ea3-8cc2-482ba9faba5d
Vargha‐Khadem, F.
9d4adb9c-2fb3-46c4-9dbb-f3b8052b5036
Nevile, B.G.R.
6e9dfd22-f645-4482-9f01-c82532179433
Jackson, G.D.
1f0399ca-2097-46f8-aed6-88832b4e841b
Gadian, David
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
Gadian, David, Connelly, A., Duncan, J.S., Cross, J.H., Kirkham, F.J., Johnson, C.L., Vargha‐Khadem, F., Nevile, B.G.R., Jackson, G.D. and Gadian, David
(1994)
H magnetic resonance spectroscopy in the investigation of intractable epilepsy.
Acta Neurologica Scandinavica, 89 (152 S), .
(doi:10.1111/j.1600-0404.1994.tb05202.x).
Abstract
We have been using proton magnetic resonance spectroscopy (1H MRS) in the investigation of adults and children with intractable epilepsy. Spectra were obtained from 2 × 2 times 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N‐acetylaspartate (NAA), creatine+phosphocreatine (Cr), and choline‐containing compounds (Cho). In comparison with control subjects, the epilepsy patients as a group show significant reductions in the NAA signal and in the NAA/Cho + Cr ratio, with increases in the Cho and Cr signals. The reduction in NAA is interpreted in terms of neuronal loss or damage, while the increase in Cr and Cho signals may be a reflection of reactive astrocytosis. 1994 Blackwell Munksgaard
This record has no associated files available for download.
More information
Published date: March 1994
Keywords:
epilepsy, magnetic resonance spectroscopy, temporal lobe.
Identifiers
Local EPrints ID: 429783
URI: http://eprints.soton.ac.uk/id/eprint/429783
ISSN: 0001-6314
PURE UUID: c1c8b8e1-4211-41f9-b7ab-f122bf71e775
Catalogue record
Date deposited: 05 Apr 2019 16:30
Last modified: 16 Mar 2024 03:22
Export record
Altmetrics
Contributors
Author:
David Gadian
Author:
A. Connelly
Author:
J.S. Duncan
Author:
J.H. Cross
Author:
C.L. Johnson
Author:
F. Vargha‐Khadem
Author:
B.G.R. Nevile
Author:
G.D. Jackson
Author:
David Gadian
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
