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Seizures and status epilepticus in childhood cerebral malaria

Seizures and status epilepticus in childhood cerebral malaria
Seizures and status epilepticus in childhood cerebral malaria

Prolonged, multiple seizures complicate a high proportion of cases of childhood cerebral malaria, and several studies have shown an association between these and neurological sequelae. We prospectively studied 65 patients (38 female) admitted to Kilifi Hospital in 1994. Electroencephalographic recordings (EEGs) were made at 12-hourly intervals, with continuous recordings made on a cerebral function analysing monitor (CFAM). Survivors were seen one month after discharge. Cerebral computerized tomography was performed on children with neurological sequelae. Sixty-two percent of patients had seizures following admission, of whom half had an episode of status epilepticus. Fifty-two percent of seizures were partial motor, 34% generalized tonic-clonic, and 14% partial with secondary generalization. In 22%, coma appeared to be due to a prolonged postictal state. Ten children had subtle motor seizures. Posterior parieto-temporal discharges were the most common EEG finding. Seven children died, eight developed neurological sequelae, and 50 (77%) recovered fully. Status epilepticus was associated with the development of neurological sequelae. Prolonged, multiple seizures may play an important part in the pathogenesis of coma in childhood cerebral malaria, and are likely to contribute to both the morbidity and mortality of this disease.

0033-5622
591-597
Crawley, J.
59f9c041-b3a3-43ae-9010-1af4c9b3fe02
Smith, S.
5f1e1446-bd4e-4593-858a-299963de4404
Kirkham, F.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Muthinji, P.
dc592d1b-3d24-45da-aedd-ccc033558d2b
Waruiru, C.
b561024b-6cfd-4285-a49a-fdc09f17064e
Marsh, K.
ef5c6f9a-c4a1-4f53-a90b-fe92821caae7
Crawley, J.
59f9c041-b3a3-43ae-9010-1af4c9b3fe02
Smith, S.
5f1e1446-bd4e-4593-858a-299963de4404
Kirkham, F.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Muthinji, P.
dc592d1b-3d24-45da-aedd-ccc033558d2b
Waruiru, C.
b561024b-6cfd-4285-a49a-fdc09f17064e
Marsh, K.
ef5c6f9a-c4a1-4f53-a90b-fe92821caae7

Crawley, J., Smith, S., Kirkham, F., Muthinji, P., Waruiru, C. and Marsh, K. (1996) Seizures and status epilepticus in childhood cerebral malaria. QJM - Monthly Journal of the Association of Physicians, 89 (8), 591-597. (doi:10.1093/qjmed/89.8.591).

Record type: Article

Abstract

Prolonged, multiple seizures complicate a high proportion of cases of childhood cerebral malaria, and several studies have shown an association between these and neurological sequelae. We prospectively studied 65 patients (38 female) admitted to Kilifi Hospital in 1994. Electroencephalographic recordings (EEGs) were made at 12-hourly intervals, with continuous recordings made on a cerebral function analysing monitor (CFAM). Survivors were seen one month after discharge. Cerebral computerized tomography was performed on children with neurological sequelae. Sixty-two percent of patients had seizures following admission, of whom half had an episode of status epilepticus. Fifty-two percent of seizures were partial motor, 34% generalized tonic-clonic, and 14% partial with secondary generalization. In 22%, coma appeared to be due to a prolonged postictal state. Ten children had subtle motor seizures. Posterior parieto-temporal discharges were the most common EEG finding. Seven children died, eight developed neurological sequelae, and 50 (77%) recovered fully. Status epilepticus was associated with the development of neurological sequelae. Prolonged, multiple seizures may play an important part in the pathogenesis of coma in childhood cerebral malaria, and are likely to contribute to both the morbidity and mortality of this disease.

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Published date: August 1996

Identifiers

Local EPrints ID: 429788
URI: https://eprints.soton.ac.uk/id/eprint/429788
ISSN: 0033-5622
PURE UUID: 6077a075-84fc-493b-8585-ae16ce4beb4b
ORCID for F. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 05 Apr 2019 16:30
Last modified: 12 Nov 2019 01:51

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Contributors

Author: J. Crawley
Author: S. Smith
Author: F. Kirkham ORCID iD
Author: P. Muthinji
Author: C. Waruiru
Author: K. Marsh

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