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Variable presentation of cerebrovascular disease in monovular twins

Variable presentation of cerebrovascular disease in monovular twins
Variable presentation of cerebrovascular disease in monovular twins

We describe twin girls with bilateral cerebrovascular disease. In one child, a diagnosis of moyamoya disease was made after presentation in infancy with an acute hemiparesis; her asymptomatic sibling was found to have significant bilateral cerebrovascular disease after neuropsychological evaluation and assessment with transcranial Doppler ultrasound. Both subjects showed a discrepancy between verbal and performance IQ and and deficits on a test of frontal-lobe function suggesting that these domains should be targeted in cognitive assessment. Family members of subjects with moyamoya are at risk of cerebrovascular disease. Clinical symptoms do not reliably predict disease and those at risk should be offered screening with non-invasive vascular imaging.

0012-1622
628-631
Ganesan, V.
0541b25d-409b-434a-b628-8df993f1d8c8
Isaacs, E.
c4bea184-8a7f-4a37-8dd5-f17cb805e462
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Ganesan, V.
0541b25d-409b-434a-b628-8df993f1d8c8
Isaacs, E.
c4bea184-8a7f-4a37-8dd5-f17cb805e462
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58

Ganesan, V., Isaacs, E. and Kirkham, F.J. (1997) Variable presentation of cerebrovascular disease in monovular twins. Developmental Medicine and Child Neurology, 39 (9), 628-631. (doi:10.1111/j.1469-8749.1997.tb07499.x).

Record type: Article

Abstract

We describe twin girls with bilateral cerebrovascular disease. In one child, a diagnosis of moyamoya disease was made after presentation in infancy with an acute hemiparesis; her asymptomatic sibling was found to have significant bilateral cerebrovascular disease after neuropsychological evaluation and assessment with transcranial Doppler ultrasound. Both subjects showed a discrepancy between verbal and performance IQ and and deficits on a test of frontal-lobe function suggesting that these domains should be targeted in cognitive assessment. Family members of subjects with moyamoya are at risk of cerebrovascular disease. Clinical symptoms do not reliably predict disease and those at risk should be offered screening with non-invasive vascular imaging.

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Published date: September 1997

Identifiers

Local EPrints ID: 429793
URI: http://eprints.soton.ac.uk/id/eprint/429793
ISSN: 0012-1622
PURE UUID: 73159aa8-bd75-405f-a38f-5bae84291439
ORCID for F.J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 05 Apr 2019 16:30
Last modified: 06 Jun 2024 01:40

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Contributors

Author: V. Ganesan
Author: E. Isaacs
Author: F.J. Kirkham ORCID iD

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