The University of Southampton
University of Southampton Institutional Repository

Noonan syndrome and moyamoya

Noonan syndrome and moyamoya
Noonan syndrome and moyamoya

We report a patient with Noonan syndrome and asymptomatic cardiac disease (supravalvular aortic stenosis and pulmonary valvular stenosis) who had frequent transient ischemic attacks. Bilateral moyamoya was evident; in addition, he manifested activated protein C resistance and was heterozygous for the factor V Leiden mutation. Anticoagulation abolished his episodes and, despite extensive cerebrovascular disease, he has no permanent neurologic deficits. The association between Noonan syndrome and moyamoya has not previously been described. Disruption of vascular development in prenatal life may have resulted in both cardiac and cerebrovascular disease in this child.

0887-8994
256-258
Ganesan, V.
0541b25d-409b-434a-b628-8df993f1d8c8
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Ganesan, V.
0541b25d-409b-434a-b628-8df993f1d8c8
Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58

Ganesan, V. and Kirkham, F.J. (1997) Noonan syndrome and moyamoya. Pediatric Neurology, 16 (3), 256-258. (doi:10.1016/S0887-8994(97)89980-8).

Record type: Article

Abstract

We report a patient with Noonan syndrome and asymptomatic cardiac disease (supravalvular aortic stenosis and pulmonary valvular stenosis) who had frequent transient ischemic attacks. Bilateral moyamoya was evident; in addition, he manifested activated protein C resistance and was heterozygous for the factor V Leiden mutation. Anticoagulation abolished his episodes and, despite extensive cerebrovascular disease, he has no permanent neurologic deficits. The association between Noonan syndrome and moyamoya has not previously been described. Disruption of vascular development in prenatal life may have resulted in both cardiac and cerebrovascular disease in this child.

Full text not available from this repository.

More information

Published date: April 1997

Identifiers

Local EPrints ID: 429801
URI: https://eprints.soton.ac.uk/id/eprint/429801
ISSN: 0887-8994
PURE UUID: 866c4743-7374-4ebb-8938-10aa514caf3c

Catalogue record

Date deposited: 05 Apr 2019 16:30
Last modified: 05 Apr 2019 16:30

Export record

Altmetrics

Contributors

Author: V. Ganesan
Author: F.J. Kirkham

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×