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The relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass

The relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass
The relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass

Objectives: Neurological impairment occurs in up to 25% of infants undergoing cardiopulmonary bypass with or without circulatory arrest. Potential causes include alterations in cerebral blood flow, hypoxia and embolisation. During cardiopulmonary bypass, arterial oxygen tension is maintained at levels which under normal conditions cause cerebral vasoconstriction; this is a potential mechanism for ischaemia. The aim of this study was to explore the relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass. Methods: Near infrared spectroscopy was used to explore the relation between arterial oxygen tension and cerebral blood flow in 14 patients (median age 8 months; range 1 month to 10 years 11 months). The relations between arterial oxygen tension, arterial carbon dioxide tension, temperature, haematocrit, pump flow rate, mean arterial pressure and cerebral blood flow, were examined using multivariate analysis. Results: There was no relation between cerebral blood flow and arterial oxygen tension, but a highly significant relation was observed between cerebral blood flow and pump flow rate, with cerebral blood flow decreasing 4.2-fold per L.m-2.min-1 decrease of pump flow rate. Conclusion: There was no relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass, but low pump flow rate may lead to reduced cerebral blood flow.

Arterial oxygen tension, Cardiopulmonary bypass, Cerebral blood flow
1010-7940
633-639
Chow, Gabriel
54191f58-cc39-493a-8eb5-98e0eedb213f
Roberts, Idris G.
518baff5-ec7b-413a-87b1-d0b384345d1c
Fallon, Penny
448d79fe-cdb4-427f-aa50-492760899806
Onoe, Masahiko
5679fb72-ed48-4341-b443-a97245adf4cb
Lloyd-Thomas, Adrian
d23f074e-01be-4ffe-b479-9b0eed40cd8b
Elliott, Martin J.
ceab4270-3052-4dae-8584-d78e35bbd4b1
Edwards, A. David
2df0b540-425b-41cc-b6c1-07e8096c9d04
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Chow, Gabriel
54191f58-cc39-493a-8eb5-98e0eedb213f
Roberts, Idris G.
518baff5-ec7b-413a-87b1-d0b384345d1c
Fallon, Penny
448d79fe-cdb4-427f-aa50-492760899806
Onoe, Masahiko
5679fb72-ed48-4341-b443-a97245adf4cb
Lloyd-Thomas, Adrian
d23f074e-01be-4ffe-b479-9b0eed40cd8b
Elliott, Martin J.
ceab4270-3052-4dae-8584-d78e35bbd4b1
Edwards, A. David
2df0b540-425b-41cc-b6c1-07e8096c9d04
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58

Chow, Gabriel, Roberts, Idris G., Fallon, Penny, Onoe, Masahiko, Lloyd-Thomas, Adrian, Elliott, Martin J., Edwards, A. David and Kirkham, Fenella J. (1997) The relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass. European Journal of Cardio-thoracic Surgery, 11 (4), 633-639. (doi:10.1016/S1010-7940(96)01073-1).

Record type: Article

Abstract

Objectives: Neurological impairment occurs in up to 25% of infants undergoing cardiopulmonary bypass with or without circulatory arrest. Potential causes include alterations in cerebral blood flow, hypoxia and embolisation. During cardiopulmonary bypass, arterial oxygen tension is maintained at levels which under normal conditions cause cerebral vasoconstriction; this is a potential mechanism for ischaemia. The aim of this study was to explore the relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass. Methods: Near infrared spectroscopy was used to explore the relation between arterial oxygen tension and cerebral blood flow in 14 patients (median age 8 months; range 1 month to 10 years 11 months). The relations between arterial oxygen tension, arterial carbon dioxide tension, temperature, haematocrit, pump flow rate, mean arterial pressure and cerebral blood flow, were examined using multivariate analysis. Results: There was no relation between cerebral blood flow and arterial oxygen tension, but a highly significant relation was observed between cerebral blood flow and pump flow rate, with cerebral blood flow decreasing 4.2-fold per L.m-2.min-1 decrease of pump flow rate. Conclusion: There was no relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass, but low pump flow rate may lead to reduced cerebral blood flow.

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More information

Published date: April 1997
Keywords: Arterial oxygen tension, Cardiopulmonary bypass, Cerebral blood flow

Identifiers

Local EPrints ID: 429803
URI: https://eprints.soton.ac.uk/id/eprint/429803
ISSN: 1010-7940
PURE UUID: 77d9084c-2f6c-4afa-b8c2-3b2d42f38dcb
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 05 Apr 2019 16:30
Last modified: 20 Jul 2019 01:05

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Contributors

Author: Gabriel Chow
Author: Idris G. Roberts
Author: Penny Fallon
Author: Masahiko Onoe
Author: Adrian Lloyd-Thomas
Author: Martin J. Elliott
Author: A. David Edwards
Author: Fenella J. Kirkham ORCID iD

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