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Cognitive deficits associated with frontal-lobe infarction in children with sickle cell disease

Cognitive deficits associated with frontal-lobe infarction in children with sickle cell disease
Cognitive deficits associated with frontal-lobe infarction in children with sickle cell disease

This study examined the cognitive manifestations of frontal-lobe infarction in a population of children with sickle cell disease (SCD). Forty-one patients with SCD underwent MRI. Five patients with stroke symptoms had large infarcts encroaching on the tissue of the frontal lobes. Four patients without symptoms had smaller frontal-lobe infarcts. The patients with stroke were significantly impaired on measures of intelligence, memory, and frontal-lobe function (Wisconsin Card Sorting Test, WCST) compared with both the patients with normal MRI scans (N = 30) and a group of sibling controls (N = 15), who did not differ from each other. Patients with covert infarction obtained scores on the intelligence tests and the WCST that fell in between those of the stroke patients and the other two groups. This trend toward impairment suggests that patients with covert infarction are at similar risk for cognitive deficits to those with stroke.

0012-1622
536-543
Watkins, K.E.
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Hewes, D.K.M.
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Connelly, A.
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Kendall, B.E.
f3bcbbb3-8fdd-4638-b9ff-3d946ebe178c
Kingsley, D.P.E.
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Evans, J.E.P.
406bcb90-8e8a-4300-858e-1c3758b58516
Gadian, D.G.
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Vargha-Khadem, F.
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Kirkham, F.J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Watkins, K.E.
ff3640b2-59ee-4991-a3d7-7d14cb2cb564
Hewes, D.K.M.
0da12a8e-8418-4b44-99c9-e9863e47bf91
Connelly, A.
0cb19e67-b09d-458b-8c30-1e9f8a279887
Kendall, B.E.
f3bcbbb3-8fdd-4638-b9ff-3d946ebe178c
Kingsley, D.P.E.
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Evans, J.E.P.
406bcb90-8e8a-4300-858e-1c3758b58516
Gadian, D.G.
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
Vargha-Khadem, F.
9d4adb9c-2fb3-46c4-9dbb-f3b8052b5036
Kirkham, F.J.
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Watkins, K.E., Hewes, D.K.M., Connelly, A., Kendall, B.E., Kingsley, D.P.E., Evans, J.E.P., Gadian, D.G., Vargha-Khadem, F. and Kirkham, F.J. (1998) Cognitive deficits associated with frontal-lobe infarction in children with sickle cell disease. Developmental Medicine and Child Neurology, 40 (8), 536-543. (doi:10.1111/j.1469-8749.1998.tb15412.x).

Record type: Article

Abstract

This study examined the cognitive manifestations of frontal-lobe infarction in a population of children with sickle cell disease (SCD). Forty-one patients with SCD underwent MRI. Five patients with stroke symptoms had large infarcts encroaching on the tissue of the frontal lobes. Four patients without symptoms had smaller frontal-lobe infarcts. The patients with stroke were significantly impaired on measures of intelligence, memory, and frontal-lobe function (Wisconsin Card Sorting Test, WCST) compared with both the patients with normal MRI scans (N = 30) and a group of sibling controls (N = 15), who did not differ from each other. Patients with covert infarction obtained scores on the intelligence tests and the WCST that fell in between those of the stroke patients and the other two groups. This trend toward impairment suggests that patients with covert infarction are at similar risk for cognitive deficits to those with stroke.

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Published date: August 1998

Identifiers

Local EPrints ID: 429804
URI: http://eprints.soton.ac.uk/id/eprint/429804
ISSN: 0012-1622
PURE UUID: 84a653d2-2e2b-4380-b28f-57e269428b9c
ORCID for F.J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 05 Apr 2019 16:30
Last modified: 16 Mar 2024 03:22

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Contributors

Author: K.E. Watkins
Author: D.K.M. Hewes
Author: A. Connelly
Author: B.E. Kendall
Author: D.P.E. Kingsley
Author: J.E.P. Evans
Author: D.G. Gadian
Author: F. Vargha-Khadem
Author: F.J. Kirkham ORCID iD

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