Hyponatraemia associated with lamotrigine in cranial diabetes insipidus
Hyponatraemia associated with lamotrigine in cranial diabetes insipidus
We report the cases of two children with cranial diabetes insipidus who were treated with lamotrigine for seizures and who had accompanying changes in desmopressin requirements. Lamotrigine is a new anticonvulsant chemically unrelated to other existing antiepileptic drugs. Studies suggest it acts at voltage-sensitive sodium channels and also decreases calcium conductance. Both of these mechanisms of action are shared by carbamazepine, which can cause hyponatraemia secondary to inappropriate secretion of antidiuretic hormone. It is possible that the effect of lamotrigine on fluid balance in the cases described is also centrally mediated.
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Mewasingh, Leena
e2ff41cf-7b9a-4990-becb-c856317a58b1
Aylett, S.
7d4b9b73-8c55-484b-8007-615b93814d52
Kirkham, F.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Stanhope, R.
847f2ddd-2f2d-4ebe-9b08-129bcb356d77
19 August 2000
Mewasingh, Leena
e2ff41cf-7b9a-4990-becb-c856317a58b1
Aylett, S.
7d4b9b73-8c55-484b-8007-615b93814d52
Kirkham, F.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Stanhope, R.
847f2ddd-2f2d-4ebe-9b08-129bcb356d77
Mewasingh, Leena, Aylett, S., Kirkham, F. and Stanhope, R.
(2000)
Hyponatraemia associated with lamotrigine in cranial diabetes insipidus.
The Lancet, 356 (9230), , [2613].
(doi:10.1016/S0140-6736(00)02613-1).
Abstract
We report the cases of two children with cranial diabetes insipidus who were treated with lamotrigine for seizures and who had accompanying changes in desmopressin requirements. Lamotrigine is a new anticonvulsant chemically unrelated to other existing antiepileptic drugs. Studies suggest it acts at voltage-sensitive sodium channels and also decreases calcium conductance. Both of these mechanisms of action are shared by carbamazepine, which can cause hyponatraemia secondary to inappropriate secretion of antidiuretic hormone. It is possible that the effect of lamotrigine on fluid balance in the cases described is also centrally mediated.
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Published date: 19 August 2000
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Local EPrints ID: 429818
URI: http://eprints.soton.ac.uk/id/eprint/429818
ISSN: 0140-6736
PURE UUID: 3c7ac992-0bb5-4397-a564-c44e83b4ef9e
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Date deposited: 05 Apr 2019 16:30
Last modified: 16 Aug 2024 01:38
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Author:
Leena Mewasingh
Author:
S. Aylett
Author:
R. Stanhope
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