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By how much can exhaled nitric oxide vary without a change in clinical status?

By how much can exhaled nitric oxide vary without a change in clinical status?
By how much can exhaled nitric oxide vary without a change in clinical status?
Background: Fractional exhaled nitric oxide (FeNO) may be a useful biomarker to guide asthma treatment. A study in children without asthma and with mild asthma suggested that FeNO may vary by up to 100% over 2 months. The aim of this study was to describe the change in FeNO over a 3 month period in children with moderate asthma who remained controlled and with stable inhaled corticosteroid (ICS) treatment.

Methods: Data from 7 clinical trials were pooled. Each trial was broken down into three-month intervals. Individuals whose asthma was controlled and with stable ICS treatment over a particular 3-month interval were identified. The absolute and relative change in FeNO over this interval was described.

Results: Data were available on 1115 children (58% male, mean age 12.6 years). FeNO values were similar in “FeNO” and “standard treatment” arms of the trials. There were 228 eligible children in the first three-month interval, 209 in the second, 294 in the third and 296 in the fourth interval. The median (interquartile range, IQR) change in FeNO during the first 3 months was +2 parts per billion, ppb (-6, +15) and values for the successive periods were +1 (-13, +10), 0 (-8, +10) and +1 (-6, +10). The median percentage change in FeNO (IQR) for the first 3 months was +10 (-28, 79) and for the next three periods were +2 (-35, 70), +1 (-24, 50) and +5 (-21, 46).

Conclusions: FeNO values varied considerably in these eligible children. The 75th centile values suggest that absolute FeNO may rise by ≤15ppb and %FeNO by ≤80% without a change in the child’s clinical status. Similarly, the 25th centile values suggest that FeNO may fall by ≤15ppb or ≤40% without a change in clinical status.
0903-1936
Fielding, Shona
f1c3725b-26a5-48fd-86d0-4d92e386e5c8
Pijnenburg, Marielle
5fa69ab2-4a84-44f5-bc82-ea852e382cc7
De Jongste, Johan
3902188e-c058-4f21-a024-148fa9c3c346
Katy, Pike
a93bbde7-2646-48b4-a6c2-4189b7f90242
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Petsky, Helen
a41e62d7-b4c2-42f5-a8a9-777c165f30d0
Chang, Anne
4fd39b50-d44b-4207-83da-73e7f9ae9901
Fritsch, Maria
583f8ce1-9d26-4124-ae85-ca256846c81b
Frischer, Thomas
f3996d47-99b5-4a51-af3b-28f0d5bbf72e
Szefler, Stanley
aa1b0268-00cb-4425-a530-5180f9672c5e
Gergen, Peter
fa2bb4bb-c97e-47cb-af11-be85da2af9d4
Vermeulen, Francoise
11ed1ab4-dec2-47e2-a69b-466935da046e
Vael, Robin
bd841c51-c08f-41c7-830b-86e28f6cbc12
Turner, Stephen
a51d875a-66bb-4a18-b5b0-18ce3dc7d15c
Fielding, Shona
f1c3725b-26a5-48fd-86d0-4d92e386e5c8
Pijnenburg, Marielle
5fa69ab2-4a84-44f5-bc82-ea852e382cc7
De Jongste, Johan
3902188e-c058-4f21-a024-148fa9c3c346
Katy, Pike
a93bbde7-2646-48b4-a6c2-4189b7f90242
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Petsky, Helen
a41e62d7-b4c2-42f5-a8a9-777c165f30d0
Chang, Anne
4fd39b50-d44b-4207-83da-73e7f9ae9901
Fritsch, Maria
583f8ce1-9d26-4124-ae85-ca256846c81b
Frischer, Thomas
f3996d47-99b5-4a51-af3b-28f0d5bbf72e
Szefler, Stanley
aa1b0268-00cb-4425-a530-5180f9672c5e
Gergen, Peter
fa2bb4bb-c97e-47cb-af11-be85da2af9d4
Vermeulen, Francoise
11ed1ab4-dec2-47e2-a69b-466935da046e
Vael, Robin
bd841c51-c08f-41c7-830b-86e28f6cbc12
Turner, Stephen
a51d875a-66bb-4a18-b5b0-18ce3dc7d15c

Fielding, Shona, Pijnenburg, Marielle, De Jongste, Johan, Katy, Pike, Roberts, Graham, Petsky, Helen, Chang, Anne, Fritsch, Maria, Frischer, Thomas, Szefler, Stanley, Gergen, Peter, Vermeulen, Francoise, Vael, Robin and Turner, Stephen (2017) By how much can exhaled nitric oxide vary without a change in clinical status? European Respiratory Journal, 50 (Suppl61), [PA4497]. (doi:10.1183/1393003.congress-2017.PA4497).

Record type: Meeting abstract

Abstract

Background: Fractional exhaled nitric oxide (FeNO) may be a useful biomarker to guide asthma treatment. A study in children without asthma and with mild asthma suggested that FeNO may vary by up to 100% over 2 months. The aim of this study was to describe the change in FeNO over a 3 month period in children with moderate asthma who remained controlled and with stable inhaled corticosteroid (ICS) treatment.

Methods: Data from 7 clinical trials were pooled. Each trial was broken down into three-month intervals. Individuals whose asthma was controlled and with stable ICS treatment over a particular 3-month interval were identified. The absolute and relative change in FeNO over this interval was described.

Results: Data were available on 1115 children (58% male, mean age 12.6 years). FeNO values were similar in “FeNO” and “standard treatment” arms of the trials. There were 228 eligible children in the first three-month interval, 209 in the second, 294 in the third and 296 in the fourth interval. The median (interquartile range, IQR) change in FeNO during the first 3 months was +2 parts per billion, ppb (-6, +15) and values for the successive periods were +1 (-13, +10), 0 (-8, +10) and +1 (-6, +10). The median percentage change in FeNO (IQR) for the first 3 months was +10 (-28, 79) and for the next three periods were +2 (-35, 70), +1 (-24, 50) and +5 (-21, 46).

Conclusions: FeNO values varied considerably in these eligible children. The 75th centile values suggest that absolute FeNO may rise by ≤15ppb and %FeNO by ≤80% without a change in the child’s clinical status. Similarly, the 25th centile values suggest that FeNO may fall by ≤15ppb or ≤40% without a change in clinical status.

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More information

e-pub ahead of print date: 6 December 2017
Published date: December 2017

Identifiers

Local EPrints ID: 429959
URI: http://eprints.soton.ac.uk/id/eprint/429959
ISSN: 0903-1936
PURE UUID: c17ea066-cfc2-48a9-9872-f5d345d61014
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 09 Apr 2019 16:30
Last modified: 10 Nov 2021 03:13

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Contributors

Author: Shona Fielding
Author: Marielle Pijnenburg
Author: Johan De Jongste
Author: Pike Katy
Author: Graham Roberts ORCID iD
Author: Helen Petsky
Author: Anne Chang
Author: Maria Fritsch
Author: Thomas Frischer
Author: Stanley Szefler
Author: Peter Gergen
Author: Francoise Vermeulen
Author: Robin Vael
Author: Stephen Turner

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