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The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome

The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome
The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome

Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients. Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice. Results: Guidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer. Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

endometrial cancer, guidance, Lynch syndrome, screening, surveillance
1098-3600
1-11
Crosbie, Emma J.
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Ryan, Neil A.J.
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Arends, Mark J.
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Bosse, Tjalling
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Burn, John
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Cornes, Joanna M.
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Crawford, Robin
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Eccles, Diana
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Frayling, Ian M.
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Ghaem-Maghami, Sadaf
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Hampel, Heather
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Kauff, Noah D.
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Kitchener, Henry C.
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Kitson, Sarah J.
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Manchanda, Ranjit
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McMahon, Raymond F.T.
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Monahan, Kevin J.
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Menon, Usha
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Møller, Pål
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Möslein, Gabriela
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Rosenthal, Adam
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Sasieni, Peter
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Seif, Mourad W.
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Singh, Naveena
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Skarrott, Pauline
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Snowsill, Tristan M.
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Steele, Robert
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Tischkowitz, Marc
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Evans, D. Gareth
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Manchester International Consensus Group,
Crosbie, Emma J.
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Ryan, Neil A.J.
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Arends, Mark J.
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Bosse, Tjalling
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Burn, John
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Cornes, Joanna M.
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Crawford, Robin
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Eccles, Diana
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Frayling, Ian M.
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Ghaem-Maghami, Sadaf
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Hampel, Heather
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Kauff, Noah D.
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Kitchener, Henry C.
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Kitson, Sarah J.
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Manchanda, Ranjit
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McMahon, Raymond F.T.
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Monahan, Kevin J.
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Menon, Usha
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Møller, Pål
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Möslein, Gabriela
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Rosenthal, Adam
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Sasieni, Peter
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Seif, Mourad W.
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Singh, Naveena
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Skarrott, Pauline
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Snowsill, Tristan M.
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Steele, Robert
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Tischkowitz, Marc
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Evans, D. Gareth
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Crosbie, Emma J., Ryan, Neil A.J., Arends, Mark J., Bosse, Tjalling, Burn, John, Cornes, Joanna M., Crawford, Robin, Eccles, Diana, Frayling, Ian M., Ghaem-Maghami, Sadaf, Hampel, Heather, Kauff, Noah D., Kitchener, Henry C., Kitson, Sarah J., Manchanda, Ranjit, McMahon, Raymond F.T., Monahan, Kevin J., Menon, Usha, Møller, Pål, Möslein, Gabriela, Rosenthal, Adam, Sasieni, Peter, Seif, Mourad W., Singh, Naveena, Skarrott, Pauline, Snowsill, Tristan M., Steele, Robert, Tischkowitz, Marc and Evans, D. Gareth , Manchester International Consensus Group, (2019) The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome. Genetics in Medicine, 1-11. (doi:10.1038/s41436-019-0489-y).

Record type: Article

Abstract

Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients. Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice. Results: Guidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer. Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

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s41436-019-0489-y - Version of Record
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Accepted/In Press date: 6 March 2019
e-pub ahead of print date: 28 March 2019
Keywords: endometrial cancer, guidance, Lynch syndrome, screening, surveillance

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Local EPrints ID: 430114
URI: https://eprints.soton.ac.uk/id/eprint/430114
ISSN: 1098-3600
PURE UUID: 89d7b3a2-52b0-4f19-b07f-4f6e338b4637

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Date deposited: 12 Apr 2019 16:30
Last modified: 14 Aug 2019 16:32

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Contributors

Author: Emma J. Crosbie
Author: Neil A.J. Ryan
Author: Mark J. Arends
Author: Tjalling Bosse
Author: John Burn
Author: Joanna M. Cornes
Author: Robin Crawford
Author: Diana Eccles
Author: Ian M. Frayling
Author: Sadaf Ghaem-Maghami
Author: Heather Hampel
Author: Noah D. Kauff
Author: Henry C. Kitchener
Author: Sarah J. Kitson
Author: Ranjit Manchanda
Author: Raymond F.T. McMahon
Author: Kevin J. Monahan
Author: Usha Menon
Author: Pål Møller
Author: Gabriela Möslein
Author: Adam Rosenthal
Author: Peter Sasieni
Author: Mourad W. Seif
Author: Naveena Singh
Author: Pauline Skarrott
Author: Tristan M. Snowsill
Author: Robert Steele
Author: Marc Tischkowitz
Author: D. Gareth Evans

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