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Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival

Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival
Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival
Mesenchymal stromal cells (MSCs) have been successfully used for the treatment of steroid-resistant graft-versus-host-disease (GvHD). However, the lack of early predictors of clinical responses impacts on the time at which to add further treatment and consequently the design of informative clinical trials. Here, we present the UK experience of one of the largest cohorts of GvHD patients undergoing MSC infusions so far reported. We show that clinical responses assessed as early as 1 week after MSC infusion predict patients' overall survival. In our cohort, cell dose, patients' age and type of organ involvement are crucial factors associated with clinical responses.
0007-1048
89-92
Galleu, Antonio
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Milojkovic, Dragana
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Deplano, Simona
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Szydlo, Richard
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Loaiza, Sandra
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Wynn, Robert
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Marks, David I.
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Richardson, Deborah
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Orchard, Kim
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Kanfer, Edward
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Tholouli, Eleni
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Saif, Muhammad
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Sivaprakasam, Ponni
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Lawson, Sarah
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Bloor, Adrian
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Pagliuca, Antonio
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Potter, Victoria
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Mehra, Varun
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Snowden, John A.
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Vora, Ajay
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Kishore, Bhuvan
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Hunter, Hannah
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Apperley, Jane F.
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Dazzi, Francesco
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Galleu, Antonio
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Milojkovic, Dragana
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Deplano, Simona
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Szydlo, Richard
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Loaiza, Sandra
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Wynn, Robert
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Marks, David I.
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Richardson, Deborah
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Orchard, Kim
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Kanfer, Edward
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Tholouli, Eleni
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Saif, Muhammad
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Sivaprakasam, Ponni
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Lawson, Sarah
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Bloor, Adrian
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Pagliuca, Antonio
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Potter, Victoria
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Mehra, Varun
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Snowden, John A.
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Vora, Ajay
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Kishore, Bhuvan
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Hunter, Hannah
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Apperley, Jane F.
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Dazzi, Francesco
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Galleu, Antonio, Milojkovic, Dragana, Deplano, Simona, Szydlo, Richard, Loaiza, Sandra, Wynn, Robert, Marks, David I., Richardson, Deborah, Orchard, Kim, Kanfer, Edward, Tholouli, Eleni, Saif, Muhammad, Sivaprakasam, Ponni, Lawson, Sarah, Bloor, Adrian, Pagliuca, Antonio, Potter, Victoria, Mehra, Varun, Snowden, John A., Vora, Ajay, Kishore, Bhuvan, Hunter, Hannah, Apperley, Jane F. and Dazzi, Francesco (2019) Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival. British Journal of Haematology, 185 (1), 89-92. (doi:10.1111/bjh.15749).

Record type: Article

Abstract

Mesenchymal stromal cells (MSCs) have been successfully used for the treatment of steroid-resistant graft-versus-host-disease (GvHD). However, the lack of early predictors of clinical responses impacts on the time at which to add further treatment and consequently the design of informative clinical trials. Here, we present the UK experience of one of the largest cohorts of GvHD patients undergoing MSC infusions so far reported. We show that clinical responses assessed as early as 1 week after MSC infusion predict patients' overall survival. In our cohort, cell dose, patients' age and type of organ involvement are crucial factors associated with clinical responses.

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More information

Accepted/In Press date: 11 December 2018
e-pub ahead of print date: 13 January 2019
Published date: April 2019

Identifiers

Local EPrints ID: 430137
URI: https://eprints.soton.ac.uk/id/eprint/430137
ISSN: 0007-1048
PURE UUID: 5ebb04a9-85a1-4759-accb-eb5cf35c9af7
ORCID for Kim Orchard: ORCID iD orcid.org/0000-0003-2276-3925

Catalogue record

Date deposited: 12 Apr 2019 16:30
Last modified: 13 Apr 2019 00:35

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Contributors

Author: Antonio Galleu
Author: Dragana Milojkovic
Author: Simona Deplano
Author: Richard Szydlo
Author: Sandra Loaiza
Author: Robert Wynn
Author: David I. Marks
Author: Deborah Richardson
Author: Kim Orchard ORCID iD
Author: Edward Kanfer
Author: Eleni Tholouli
Author: Muhammad Saif
Author: Ponni Sivaprakasam
Author: Sarah Lawson
Author: Adrian Bloor
Author: Antonio Pagliuca
Author: Victoria Potter
Author: Varun Mehra
Author: John A. Snowden
Author: Ajay Vora
Author: Bhuvan Kishore
Author: Hannah Hunter
Author: Jane F. Apperley
Author: Francesco Dazzi

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