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Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia

Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia
Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors. Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12–19, 20–29, 30–34 and 35–40 weeks of gestation. Results: D-Di was lower at 12–19 weeks and higher at 30–34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn’t differ between groups. Conclusion: D-Di was able to discriminate these groups of women at 12–19 and 30–34 weeks of gestation.

D-dimer, hypercoagulability, longitudinal study, PAI-1, Preeclampsia
1064-1955
58-63
Lucena, Flávia Campos
81845070-8d10-43e9-ba90-99bcbe7745fd
Lage, Eura Martins
8de24f57-4c52-4fe6-b376-cc64cd7c69b4
Teixeira, Patrícia Gonçalves
3184ea55-ff8a-4df6-ad84-c1d67653c954
Barbosa, Alexandre Simões
da159d03-485e-473c-b63d-8f1d3c14819e
Diniz, Rejane
e33577fb-e9e1-4f29-a650-fa719afc0cc5
Lwaleed, Bashir
e7c59131-82ad-4a14-a227-7370e91e3f21
Talvani, André
53aad1da-2c0f-41cf-9dd8-e4c0a02573a0
Alpoim, Patrícia Nessralla
2a92b0c0-0932-4106-a7fd-351e0cee40f6
Perucci, Luiza Oliveira
01c1b356-cc59-43ed-b465-63ccb7f70790
Dusse, Luci Maria Sant Ana
d2f2ed62-d7b0-42d0-a0d1-4edec06187a6
Lucena, Flávia Campos
81845070-8d10-43e9-ba90-99bcbe7745fd
Lage, Eura Martins
8de24f57-4c52-4fe6-b376-cc64cd7c69b4
Teixeira, Patrícia Gonçalves
3184ea55-ff8a-4df6-ad84-c1d67653c954
Barbosa, Alexandre Simões
da159d03-485e-473c-b63d-8f1d3c14819e
Diniz, Rejane
e33577fb-e9e1-4f29-a650-fa719afc0cc5
Lwaleed, Bashir
e7c59131-82ad-4a14-a227-7370e91e3f21
Talvani, André
53aad1da-2c0f-41cf-9dd8-e4c0a02573a0
Alpoim, Patrícia Nessralla
2a92b0c0-0932-4106-a7fd-351e0cee40f6
Perucci, Luiza Oliveira
01c1b356-cc59-43ed-b465-63ccb7f70790
Dusse, Luci Maria Sant Ana
d2f2ed62-d7b0-42d0-a0d1-4edec06187a6

Lucena, Flávia Campos, Lage, Eura Martins, Teixeira, Patrícia Gonçalves, Barbosa, Alexandre Simões, Diniz, Rejane, Lwaleed, Bashir, Talvani, André, Alpoim, Patrícia Nessralla, Perucci, Luiza Oliveira and Dusse, Luci Maria Sant Ana (2019) Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia. Hypertension in Pregnancy, 38 (1), 58-63. (doi:10.1080/10641955.2019.1577435).

Record type: Article

Abstract

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors. Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12–19, 20–29, 30–34 and 35–40 weeks of gestation. Results: D-Di was lower at 12–19 weeks and higher at 30–34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn’t differ between groups. Conclusion: D-Di was able to discriminate these groups of women at 12–19 and 30–34 weeks of gestation.

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More information

Accepted/In Press date: 17 January 2019
e-pub ahead of print date: 13 February 2019
Published date: 2019
Keywords: D-dimer, hypercoagulability, longitudinal study, PAI-1, Preeclampsia

Identifiers

Local EPrints ID: 430138
URI: https://eprints.soton.ac.uk/id/eprint/430138
ISSN: 1064-1955
PURE UUID: 198f38d5-1ccc-4661-8191-6bb83bb3358d

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Date deposited: 12 Apr 2019 16:30
Last modified: 12 Apr 2019 16:30

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Contributors

Author: Flávia Campos Lucena
Author: Eura Martins Lage
Author: Patrícia Gonçalves Teixeira
Author: Alexandre Simões Barbosa
Author: Rejane Diniz
Author: Bashir Lwaleed
Author: André Talvani
Author: Patrícia Nessralla Alpoim
Author: Luiza Oliveira Perucci
Author: Luci Maria Sant Ana Dusse

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