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Serum free thiols in type 2 diabetes mellitus: A prospective study

Serum free thiols in type 2 diabetes mellitus: A prospective study
Serum free thiols in type 2 diabetes mellitus: A prospective study

Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status.

Methods: R-SH were measured in serum of 943 T2DM outpatients (55% males, 65 years and HbA1c of 6.7% (50 mmol/mol)) with a follow-up period of 1.2 years.

Results: In the highest R-SH tertile patients were younger, more often men, had less microvascular complications, lower HbA1c and were more often treated nutritionally or with oral glucose-lowering drugs. Age- and sex adjusted hazard ratios for developing micro-, macro- or any complication plus death were 0.994, 0.992 and 0.993: even after adjustment for potential confounders. The Harrell's C statistic to predict microvascular complications or any complication plus death was higher in the models with R-SH than in those without R-SH.

Conclusions: Although R-SH concentrations were associated with a favourable disease status, it did not add to the predictive capacity for long-term complications. Based on the current data R-SH seems unsuitable as a prognostic marker in T2DM.

2214-6237
100182
Schillern, Emmelien E.M.
3839bbd4-3018-4d32-abdf-ad4d760ceb46
Pasch, Andreas
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Feelisch, Martin
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Waanders, Femke
637ac109-85ee-4e6e-9097-f99da9ec9337
Hendriks, Steven H.
55c63758-00d2-41a4-9ba6-feaa91c1787f
Mencke, Rik
67a83dd2-5c60-49f3-88ce-b0abc237fc15
Harms, Geert
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Groenier, Klaas H.
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Bilo, Henk J.G.
c3b75e49-87e1-4200-8a3c-48febac342b1
Hillebrands, Jan-Luuk
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van Goor, Harry
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van Dijk, Peter R.
b2640d70-4120-43c6-bc5c-2d7c737726a5
Schillern, Emmelien E.M.
3839bbd4-3018-4d32-abdf-ad4d760ceb46
Pasch, Andreas
5f5d9b34-4d9e-40a4-9326-fa1cd352717d
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Waanders, Femke
637ac109-85ee-4e6e-9097-f99da9ec9337
Hendriks, Steven H.
55c63758-00d2-41a4-9ba6-feaa91c1787f
Mencke, Rik
67a83dd2-5c60-49f3-88ce-b0abc237fc15
Harms, Geert
71b864e4-4dfe-4120-87d5-497b9325709f
Groenier, Klaas H.
151d5adc-034a-4502-8694-f93381b7ddc9
Bilo, Henk J.G.
c3b75e49-87e1-4200-8a3c-48febac342b1
Hillebrands, Jan-Luuk
25949d83-4132-42aa-bb3c-c710cb5e8d1b
van Goor, Harry
6e4f96a5-c749-43b6-a488-6af71f932dc3
van Dijk, Peter R.
b2640d70-4120-43c6-bc5c-2d7c737726a5

Schillern, Emmelien E.M., Pasch, Andreas, Feelisch, Martin, Waanders, Femke, Hendriks, Steven H., Mencke, Rik, Harms, Geert, Groenier, Klaas H., Bilo, Henk J.G., Hillebrands, Jan-Luuk, van Goor, Harry and van Dijk, Peter R. (2019) Serum free thiols in type 2 diabetes mellitus: A prospective study. Journal of Clinical & Translational Endocrinology, 16, 100182. (doi:10.1016/j.jcte.2019.100182).

Record type: Article

Abstract

Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status.

Methods: R-SH were measured in serum of 943 T2DM outpatients (55% males, 65 years and HbA1c of 6.7% (50 mmol/mol)) with a follow-up period of 1.2 years.

Results: In the highest R-SH tertile patients were younger, more often men, had less microvascular complications, lower HbA1c and were more often treated nutritionally or with oral glucose-lowering drugs. Age- and sex adjusted hazard ratios for developing micro-, macro- or any complication plus death were 0.994, 0.992 and 0.993: even after adjustment for potential confounders. The Harrell's C statistic to predict microvascular complications or any complication plus death was higher in the models with R-SH than in those without R-SH.

Conclusions: Although R-SH concentrations were associated with a favourable disease status, it did not add to the predictive capacity for long-term complications. Based on the current data R-SH seems unsuitable as a prognostic marker in T2DM.

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More information

Accepted/In Press date: 4 February 2019
e-pub ahead of print date: 28 February 2019
Published date: June 2019

Identifiers

Local EPrints ID: 430264
URI: http://eprints.soton.ac.uk/id/eprint/430264
ISSN: 2214-6237
PURE UUID: 714abac9-f842-4ba1-96bd-061be1c3d737
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 23 Apr 2019 16:30
Last modified: 22 Nov 2021 03:02

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Contributors

Author: Emmelien E.M. Schillern
Author: Andreas Pasch
Author: Martin Feelisch ORCID iD
Author: Femke Waanders
Author: Steven H. Hendriks
Author: Rik Mencke
Author: Geert Harms
Author: Klaas H. Groenier
Author: Henk J.G. Bilo
Author: Jan-Luuk Hillebrands
Author: Harry van Goor
Author: Peter R. van Dijk

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