The future of asthma care: Personalized asthma treatment
The future of asthma care: Personalized asthma treatment
Although once considered a single disease entity, asthma is now known to be a complex inflammatory disease engaging a range of causal pathways. The most frequent forms of asthma are identified by sputum/blood eosinophilia and activation of type 2 inflammatory pathways involving interleukins-3, -4, -5, and granulocyte-macrophage colony-stimulating factor. The use of diagnostics that identify T2 engagement linked to the selective use of highly targeted biologics has opened up a new way of managing severe disease. Novel technologies, such as wearables and intelligent inhalers, enable real-time remote monitoring of asthma, creating a unique opportunity for personalized health care.
Asthma, Biologics, Companion diagnostics, Digital self-management, mHealth, Personalized health care
227-241
Holgate, Stephen T.
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Walker, Samantha
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West, Brigitte
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Boycott, Kay
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1 March 2019
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Walker, Samantha
efd94eef-c319-4d3b-be10-61cb2b7cb5e7
West, Brigitte
23912cdb-dca1-454e-979c-cbd137bb493b
Boycott, Kay
0f62a49d-2577-4590-9d38-f8d2974d7155
Holgate, Stephen T., Walker, Samantha, West, Brigitte and Boycott, Kay
(2019)
The future of asthma care: Personalized asthma treatment.
Clinics in Chest Medicine, 40 (1), .
(doi:10.1016/j.ccm.2018.10.013).
Abstract
Although once considered a single disease entity, asthma is now known to be a complex inflammatory disease engaging a range of causal pathways. The most frequent forms of asthma are identified by sputum/blood eosinophilia and activation of type 2 inflammatory pathways involving interleukins-3, -4, -5, and granulocyte-macrophage colony-stimulating factor. The use of diagnostics that identify T2 engagement linked to the selective use of highly targeted biologics has opened up a new way of managing severe disease. Novel technologies, such as wearables and intelligent inhalers, enable real-time remote monitoring of asthma, creating a unique opportunity for personalized health care.
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e-pub ahead of print date: 25 January 2019
Published date: 1 March 2019
Keywords:
Asthma, Biologics, Companion diagnostics, Digital self-management, mHealth, Personalized health care
Identifiers
Local EPrints ID: 430394
URI: http://eprints.soton.ac.uk/id/eprint/430394
ISSN: 0272-5231
PURE UUID: 5c2c5767-d7c9-41de-932d-05d2b9fa84eb
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Date deposited: 26 Apr 2019 16:30
Last modified: 16 Mar 2024 00:12
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Author:
Samantha Walker
Author:
Brigitte West
Author:
Kay Boycott
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