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AC electrokinetic biased deterministic lateral displacement for tunable particle

AC electrokinetic biased deterministic lateral displacement for tunable particle
AC electrokinetic biased deterministic lateral displacement for tunable particle
We describe a novel particle separation technique that combines deterministic lateral displacement (DLD) with orthogonal electrokinetic forces. DLD is a microfluidic technique for continuous flow particle separation based on size. We describe new tunable devices that use a combination of AC electric fields with DLD to separate particles below the critical diameter. Planar electrodes were integrated into a classical DLD device to produce a force orthogonal to the fluid flow direction. Experiments with 3.0 µm, 1.0 µm and 500 nm diameter microspheres show that at low frequencies (up to 500 Hz) particles oscillate in the direction of the field due to Electrophoretic (EP)/Electroosmotic (EO) forces. As the frequency of the field increases, the amplitude of these oscillations vanishes and, eventually dielectrophoresis (DEP) becomes the dominant electrokinetic force on the particles (DEP arises from electric field inhomogeneities caused by the presence of the DLD posts). Both mechanisms alter the paths of the particles inside the DLD devices leading to enhanced sorting of particles below the critical diameter of the device.
1473-0197
1386-1396
Calero Martin, Victor
a979e99e-b007-4e9e-ab19-11136ad76ed6
Garcia-Sanchez, Pablo
9f2b8e4f-0c15-4cff-9f3b-91ce213c4ca5
Honrado, Carlos M
7d6e0aa5-1ab5-4e54-8595-3acd6050f93b
Ramos, Antonio
79d60433-0c6b-4eaa-80ac-e2f61e704f72
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Calero Martin, Victor
a979e99e-b007-4e9e-ab19-11136ad76ed6
Garcia-Sanchez, Pablo
9f2b8e4f-0c15-4cff-9f3b-91ce213c4ca5
Honrado, Carlos M
7d6e0aa5-1ab5-4e54-8595-3acd6050f93b
Ramos, Antonio
79d60433-0c6b-4eaa-80ac-e2f61e704f72
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Calero Martin, Victor, Garcia-Sanchez, Pablo, Honrado, Carlos M, Ramos, Antonio and Morgan, Hywel (2019) AC electrokinetic biased deterministic lateral displacement for tunable particle. Lab on a Chip, 19 (8), 1386-1396. (doi:10.1039/C8LC01416G).

Record type: Article

Abstract

We describe a novel particle separation technique that combines deterministic lateral displacement (DLD) with orthogonal electrokinetic forces. DLD is a microfluidic technique for continuous flow particle separation based on size. We describe new tunable devices that use a combination of AC electric fields with DLD to separate particles below the critical diameter. Planar electrodes were integrated into a classical DLD device to produce a force orthogonal to the fluid flow direction. Experiments with 3.0 µm, 1.0 µm and 500 nm diameter microspheres show that at low frequencies (up to 500 Hz) particles oscillate in the direction of the field due to Electrophoretic (EP)/Electroosmotic (EO) forces. As the frequency of the field increases, the amplitude of these oscillations vanishes and, eventually dielectrophoresis (DEP) becomes the dominant electrokinetic force on the particles (DEP arises from electric field inhomogeneities caused by the presence of the DLD posts). Both mechanisms alter the paths of the particles inside the DLD devices leading to enhanced sorting of particles below the critical diameter of the device.

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More information

Accepted/In Press date: 15 March 2019
e-pub ahead of print date: 19 March 2019

Identifiers

Local EPrints ID: 430421
URI: https://eprints.soton.ac.uk/id/eprint/430421
ISSN: 1473-0197
PURE UUID: 09792c4a-eac3-4db3-aa32-4c0bee9dc660
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 30 Apr 2019 16:30
Last modified: 20 Aug 2019 00:36

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