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Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid

Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid
Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid
In Dissolution-Dynamic Nuclear Polarization, nuclear spins are hyperpolarized at cryogenic temperatures using radicals and microwave irradiation. The hyperpolarized solid is dissolved with hot solvent and the solution is transferred to a secondary magnet where strongly enhanced magnetic resonance signals are observed. Here we present a method for transferring the hyperpolarized solid. A bullet containing the frozen, hyperpolarized sample is ejected using pressurized helium gas, and shot into a receiving structure in the secondary magnet, where the bullet is retained and the polarized solid is dissolved rapidly. The transfer takes approximately 70 ms. A solenoid, wound along the entire transfer path ensures adiabatic transfer and limits radical-induced low-field relaxation. The method is fast and scalable towards small volumes suitable for high-resolution nuclear magnetic resonance spectroscopy while maintaining high concentrations of the target molecule. Polarization levels of approximately 30% have been observed for 1-13C-labelled pyruvic acid in solution.
2041-1723
Kouril, Karel
75bde80c-90bd-49c4-8b89-ec1a7b39363a
Kourilova, Hana
2ca1e000-e47e-4bd2-a6dc-ce9a93e30777
Bartram, Samuel
334719d9-120a-40c3-a5e2-d976212f97d4
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Meier, Benno
ed19bfd6-3347-43f1-9e1a-06e6586ee4d1
Kouril, Karel
75bde80c-90bd-49c4-8b89-ec1a7b39363a
Kourilova, Hana
2ca1e000-e47e-4bd2-a6dc-ce9a93e30777
Bartram, Samuel
334719d9-120a-40c3-a5e2-d976212f97d4
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Meier, Benno
ed19bfd6-3347-43f1-9e1a-06e6586ee4d1

Kouril, Karel, Kourilova, Hana, Bartram, Samuel, Levitt, Malcolm H. and Meier, Benno (2019) Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid. Nature Communications, 10, [1733]. (doi:10.1038/s41467-019-09726-5).

Record type: Article

Abstract

In Dissolution-Dynamic Nuclear Polarization, nuclear spins are hyperpolarized at cryogenic temperatures using radicals and microwave irradiation. The hyperpolarized solid is dissolved with hot solvent and the solution is transferred to a secondary magnet where strongly enhanced magnetic resonance signals are observed. Here we present a method for transferring the hyperpolarized solid. A bullet containing the frozen, hyperpolarized sample is ejected using pressurized helium gas, and shot into a receiving structure in the secondary magnet, where the bullet is retained and the polarized solid is dissolved rapidly. The transfer takes approximately 70 ms. A solenoid, wound along the entire transfer path ensures adiabatic transfer and limits radical-induced low-field relaxation. The method is fast and scalable towards small volumes suitable for high-resolution nuclear magnetic resonance spectroscopy while maintaining high concentrations of the target molecule. Polarization levels of approximately 30% have been observed for 1-13C-labelled pyruvic acid in solution.

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More information

Accepted/In Press date: 27 February 2019
e-pub ahead of print date: 15 April 2019
Published date: 15 April 2019

Identifiers

Local EPrints ID: 430423
URI: http://eprints.soton.ac.uk/id/eprint/430423
ISSN: 2041-1723
PURE UUID: 98b67a5b-431e-4895-ab73-a98dbf358d37
ORCID for Karel Kouril: ORCID iD orcid.org/0000-0003-4884-1637
ORCID for Malcolm H. Levitt: ORCID iD orcid.org/0000-0001-9878-1180
ORCID for Benno Meier: ORCID iD orcid.org/0000-0003-2258-1507

Catalogue record

Date deposited: 30 Apr 2019 16:30
Last modified: 26 Nov 2021 05:50

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Contributors

Author: Karel Kouril ORCID iD
Author: Hana Kourilova
Author: Samuel Bartram
Author: Benno Meier ORCID iD

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