Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid
Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid
In Dissolution-Dynamic Nuclear Polarization, nuclear spins are hyperpolarized at cryogenic temperatures using radicals and microwave irradiation. The hyperpolarized solid is dissolved with hot solvent and the solution is transferred to a secondary magnet where strongly enhanced magnetic resonance signals are observed. Here we present a method for transferring the hyperpolarized solid. A bullet containing the frozen, hyperpolarized sample is ejected using pressurized helium gas, and shot into a receiving structure in the secondary magnet, where the bullet is retained and the polarized solid is dissolved rapidly. The transfer takes approximately 70 ms. A solenoid, wound along the entire transfer path ensures adiabatic transfer and limits radical-induced low-field relaxation. The method is fast and scalable towards small volumes suitable for high-resolution nuclear magnetic resonance spectroscopy while maintaining high concentrations of the target molecule. Polarization levels of approximately 30% have been observed for 1-13C-labelled pyruvic acid in solution.
Kouril, Karel
75bde80c-90bd-49c4-8b89-ec1a7b39363a
Kourilova, Hana
2ca1e000-e47e-4bd2-a6dc-ce9a93e30777
Bartram, Samuel
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Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Meier, Benno
ed19bfd6-3347-43f1-9e1a-06e6586ee4d1
15 April 2019
Kouril, Karel
75bde80c-90bd-49c4-8b89-ec1a7b39363a
Kourilova, Hana
2ca1e000-e47e-4bd2-a6dc-ce9a93e30777
Bartram, Samuel
334719d9-120a-40c3-a5e2-d976212f97d4
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Meier, Benno
ed19bfd6-3347-43f1-9e1a-06e6586ee4d1
Kouril, Karel, Kourilova, Hana, Bartram, Samuel, Levitt, Malcolm H. and Meier, Benno
(2019)
Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid.
Nature Communications, 10, [1733].
(doi:10.1038/s41467-019-09726-5).
Abstract
In Dissolution-Dynamic Nuclear Polarization, nuclear spins are hyperpolarized at cryogenic temperatures using radicals and microwave irradiation. The hyperpolarized solid is dissolved with hot solvent and the solution is transferred to a secondary magnet where strongly enhanced magnetic resonance signals are observed. Here we present a method for transferring the hyperpolarized solid. A bullet containing the frozen, hyperpolarized sample is ejected using pressurized helium gas, and shot into a receiving structure in the secondary magnet, where the bullet is retained and the polarized solid is dissolved rapidly. The transfer takes approximately 70 ms. A solenoid, wound along the entire transfer path ensures adiabatic transfer and limits radical-induced low-field relaxation. The method is fast and scalable towards small volumes suitable for high-resolution nuclear magnetic resonance spectroscopy while maintaining high concentrations of the target molecule. Polarization levels of approximately 30% have been observed for 1-13C-labelled pyruvic acid in solution.
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Accepted/In Press date: 27 February 2019
e-pub ahead of print date: 15 April 2019
Published date: 15 April 2019
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Local EPrints ID: 430423
URI: http://eprints.soton.ac.uk/id/eprint/430423
ISSN: 2041-1723
PURE UUID: 98b67a5b-431e-4895-ab73-a98dbf358d37
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Date deposited: 30 Apr 2019 16:30
Last modified: 16 Mar 2024 07:40
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Author:
Karel Kouril
Author:
Hana Kourilova
Author:
Samuel Bartram
Author:
Benno Meier
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