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Mapping vaccination coverage to explore the effects of delivery mechanisms and inform vaccination strategies

Mapping vaccination coverage to explore the effects of delivery mechanisms and inform vaccination strategies
Mapping vaccination coverage to explore the effects of delivery mechanisms and inform vaccination strategies

The success of vaccination programs depends largely on the mechanisms used in vaccine delivery. National immunization programs offer childhood vaccines through fixed and outreach services within the health system and often, additional supplementary immunization activities (SIAs) are undertaken to fill gaps and boost coverage. Here, we map predicted coverage at 1 × 1 km spatial resolution in five low- and middle-income countries to identify areas that are under-vaccinated via each delivery method using Demographic and Health Surveys data. We compare estimates of the coverage of the third dose of diphtheria-tetanus-pertussis-containing vaccine (DTP3), which is typically delivered through routine immunization (RI), with those of measles-containing vaccine (MCV) for which SIAs are also undertaken. We find that SIAs have boosted MCV coverage in some places, but not in others, particularly where RI had been deficient, as depicted by DTP coverage. The modelling approaches outlined here can help to guide geographical prioritization and strategy design.

2041-1723
Utazi, C. Edson
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Thorley, Julia
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Alegana, Victor A.
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Ferrari, Matthew J.
3255ed70-b9b8-4262-a96e-66b6ddb3d2df
Takahashi, Saki
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Metcalf, C. Jessica E.
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Lessler, Justin
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Cutts, Felicity T.
25ed9d13-371b-4f1a-a15d-ca20f7e0d502
Tatem, Andrew J.
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Utazi, C. Edson
e69ca81e-fb23-4bc1-99a5-25c9e0f4d6f9
Thorley, Julia
d79524b8-5f1a-45cb-8b9a-89751ae461db
Alegana, Victor A.
f5bd6ab7-459e-4122-984f-2bdb5f906d82
Ferrari, Matthew J.
3255ed70-b9b8-4262-a96e-66b6ddb3d2df
Takahashi, Saki
0d9c9730-2ec8-4937-9330-ff031c54a65c
Metcalf, C. Jessica E.
ce1431b5-f784-4552-b66c-52fcb08f095c
Lessler, Justin
bcf6536e-e3fb-4acb-820e-5c209f006b87
Cutts, Felicity T.
25ed9d13-371b-4f1a-a15d-ca20f7e0d502
Tatem, Andrew J.
6c6de104-a5f9-46e0-bb93-a1a7c980513e

Utazi, C. Edson, Thorley, Julia, Alegana, Victor A., Ferrari, Matthew J., Takahashi, Saki, Metcalf, C. Jessica E., Lessler, Justin, Cutts, Felicity T. and Tatem, Andrew J. (2019) Mapping vaccination coverage to explore the effects of delivery mechanisms and inform vaccination strategies. Nature Communications, 10 (1), [1633]. (doi:10.1038/s41467-019-09611-1).

Record type: Article

Abstract

The success of vaccination programs depends largely on the mechanisms used in vaccine delivery. National immunization programs offer childhood vaccines through fixed and outreach services within the health system and often, additional supplementary immunization activities (SIAs) are undertaken to fill gaps and boost coverage. Here, we map predicted coverage at 1 × 1 km spatial resolution in five low- and middle-income countries to identify areas that are under-vaccinated via each delivery method using Demographic and Health Surveys data. We compare estimates of the coverage of the third dose of diphtheria-tetanus-pertussis-containing vaccine (DTP3), which is typically delivered through routine immunization (RI), with those of measles-containing vaccine (MCV) for which SIAs are also undertaken. We find that SIAs have boosted MCV coverage in some places, but not in others, particularly where RI had been deficient, as depicted by DTP coverage. The modelling approaches outlined here can help to guide geographical prioritization and strategy design.

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s41467-019-09611-1 - Version of Record
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More information

Accepted/In Press date: 21 March 2019
e-pub ahead of print date: 9 April 2019
Published date: 1 December 2019

Identifiers

Local EPrints ID: 430443
URI: http://eprints.soton.ac.uk/id/eprint/430443
ISSN: 2041-1723
PURE UUID: b81eceb0-fb45-4c53-bbdf-8739f0dc53d9
ORCID for Victor A. Alegana: ORCID iD orcid.org/0000-0001-5177-9227
ORCID for Andrew J. Tatem: ORCID iD orcid.org/0000-0002-7270-941X

Catalogue record

Date deposited: 01 May 2019 16:30
Last modified: 07 Oct 2020 02:06

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