Zhao, Bingcong, Li, Zhigang, Wang, Yuanzheng, Ma, Xuehong, Wang, Xiangqun, Wang, Xueqin, Liu, Jianping, Huang, Yong, Zhang, Jianbin, Li, Liqin, Hu, Xiaoyang, Jiang, Jinfeng, Qu, Shanshan, Chai, Qianyun, Song, Meng, Yang, Xinjing, Bao, Tuya and Fei, Yutong (2019) Manual or electroacupuncture as an add-on therapy to SSRIs for depression: A randomized controlled trial. Journal of Psychiatric Research, 114, 24-33. (doi:10.1016/j.jpsychires.2019.04.005).
Abstract
Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants, however, only around 60% of patients could benefit from them. Acupuncture is supported by insufficient evidence to help with symptom relieving and SSRIs tolerance. This pragmatic randomized controlled trial compared SSRIs alone versus SSRIs together with manual acupuncture (MA) or electroacupuncture (EA) in moderate to severe depressed patients. Patients were randomly allocated to receive MA + SSRIs (161), EA + SSRIs (160), or SSRIs alone (156) for six weeks, and then followed up for another four weeks. The primary outcome was response rate of the 17-item Hamilton Depression Scale (HAMD-17) at 6th week. The secondary outcomes were HAMD-17 (remission rate, early onset rate, total score), Self-Rating Depression Scale (SDS: total score), Clinical Global Impression (CGI), Rating Scale for Side Effects (SERS: total and domain scores), number of patients with adjusted dosage of SSRIs and adverse events (AEs). Both MA + SSRIs and EA + SSRIs were significantly better than SSRIs at 6th week on HAMD-17 response rate (RR = 1.21, 95% CI 1.04, 1.42, P = 0.013; RR = 1.27, 95% CI 1.09, 1.48, P = 0.0014), HAMD-17 early onset rate (P
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