Association between non-alcoholic fatty liver disease and decreased lung function in adults: a systematic review and meta-analysis
Association between non-alcoholic fatty liver disease and decreased lung function in adults: a systematic review and meta-analysis
Aim. - Recent observational studies assessed the association between non-alcoholic fatty liver disease (NAFLD) and lung function in adults, but the magnitude of this association remains uncertain. We estimated the magnitude of the association between NAFLD and lung function on spirometry (predicted forced expiratory volume in 1 sec [FEV1] and forced vital capacity [FVC]).
Methods. - We searched publication databases using predefined keywords to identify studies (published up to October 4, 2018), in which NAFLD was diagnosed by imaging or biochemistry (no studies with biopsy-proven NAFLD were available). Data from selected studies were extracted, and meta-analysis was performed using random-effects modelling.
Results. - Six observational studies (5 cross-sectional and 1 longitudinal) with aggregate data on 133,707 individuals (27.8% with NAFLD) of predominantly Asian ethnicity (74.6%) were included in the final analysis. There were significant differences in predicted FEV1 (n = 5 studies; pooled weighted mean difference [WMD]: -2.43%, 95%CI -3.28 to -1.58; I2 = 69.7%) and predicted FVC (pooled WMD: -2.96%, 95%CI -4.75 to -1.17; I2 = 91.7%) between individuals with and without NAFLD. Decreased FEV1 and FVC at baseline were also independently associated with a ~15% increased risk of incident NAFLD (n = 1 study in Korean individuals). Subgroup analyses did not materially modify these findings.
Conclusions. - NAFLD is associated with significant reductions of both FEV1 and FVC in Asian and United States adults, and such small, but significant, reductions of lung volumes at baseline may be also associated with increased NAFLD incidence in Asian individuals. Further research is needed to better elucidate the link between NAFLD and impaired lung volumes.
536-544
Mantovani, Alessandro
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Lonardo, Amedeo
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Vinco, Giulia
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Zoppini, Giacomo
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Lippi, Giuseppe
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Bonora, Enzo
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Loomba, Rohit
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Tilg, Herbert
ef8597c1-ea86-4416-aa92-be76c96d65fa
Byrne, Christopher
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Fabbri, Leonardo
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Targher, Giovanni
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Mantovani, Alessandro
19fc8a1f-60fe-403a-b70e-6b6884929e03
Lonardo, Amedeo
5fbf6088-fc4c-4d20-8314-ca692e613263
Vinco, Giulia
a0b3b8ed-c012-4919-bba5-9aaa57ff7889
Zoppini, Giacomo
6a7b2a3d-af98-4b8e-abce-c521d2ec5751
Lippi, Giuseppe
b954d1a3-54e6-48f5-8104-88802613db63
Bonora, Enzo
98e35343-30ac-45f5-8399-4fd04baa6c70
Loomba, Rohit
1aeda66d-b894-4e47-b8b7-2cb2405b7bfc
Tilg, Herbert
ef8597c1-ea86-4416-aa92-be76c96d65fa
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Fabbri, Leonardo
4c4b40f0-b375-4f57-9def-a33ca8e9cf19
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Mantovani, Alessandro, Lonardo, Amedeo, Vinco, Giulia, Zoppini, Giacomo, Lippi, Giuseppe, Bonora, Enzo, Loomba, Rohit, Tilg, Herbert, Byrne, Christopher, Fabbri, Leonardo and Targher, Giovanni
(2019)
Association between non-alcoholic fatty liver disease and decreased lung function in adults: a systematic review and meta-analysis.
Diabetes & Metabolism, 45 (6), .
(doi:10.1016/j.diabet.2019.04.008).
Abstract
Aim. - Recent observational studies assessed the association between non-alcoholic fatty liver disease (NAFLD) and lung function in adults, but the magnitude of this association remains uncertain. We estimated the magnitude of the association between NAFLD and lung function on spirometry (predicted forced expiratory volume in 1 sec [FEV1] and forced vital capacity [FVC]).
Methods. - We searched publication databases using predefined keywords to identify studies (published up to October 4, 2018), in which NAFLD was diagnosed by imaging or biochemistry (no studies with biopsy-proven NAFLD were available). Data from selected studies were extracted, and meta-analysis was performed using random-effects modelling.
Results. - Six observational studies (5 cross-sectional and 1 longitudinal) with aggregate data on 133,707 individuals (27.8% with NAFLD) of predominantly Asian ethnicity (74.6%) were included in the final analysis. There were significant differences in predicted FEV1 (n = 5 studies; pooled weighted mean difference [WMD]: -2.43%, 95%CI -3.28 to -1.58; I2 = 69.7%) and predicted FVC (pooled WMD: -2.96%, 95%CI -4.75 to -1.17; I2 = 91.7%) between individuals with and without NAFLD. Decreased FEV1 and FVC at baseline were also independently associated with a ~15% increased risk of incident NAFLD (n = 1 study in Korean individuals). Subgroup analyses did not materially modify these findings.
Conclusions. - NAFLD is associated with significant reductions of both FEV1 and FVC in Asian and United States adults, and such small, but significant, reductions of lung volumes at baseline may be also associated with increased NAFLD incidence in Asian individuals. Further research is needed to better elucidate the link between NAFLD and impaired lung volumes.
Text
NAFLD lung function in adults Revised R1
- Accepted Manuscript
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Figure 1 PRISMA Flow chart
- Accepted Manuscript
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Figure 2 Predicted FEV1 and FVC
- Accepted Manuscript
Text
Figure 3_Lung function and incident NAFLD
- Accepted Manuscript
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Accepted/In Press date: 28 April 2019
e-pub ahead of print date: 5 May 2019
Identifiers
Local EPrints ID: 430481
URI: http://eprints.soton.ac.uk/id/eprint/430481
ISSN: 1262-3636
PURE UUID: 6af0d96b-b0ac-40f4-b4ed-10f5ca971fd3
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Date deposited: 02 May 2019 16:30
Last modified: 16 Mar 2024 07:48
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Contributors
Author:
Alessandro Mantovani
Author:
Amedeo Lonardo
Author:
Giulia Vinco
Author:
Giacomo Zoppini
Author:
Giuseppe Lippi
Author:
Enzo Bonora
Author:
Rohit Loomba
Author:
Herbert Tilg
Author:
Leonardo Fabbri
Author:
Giovanni Targher
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