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The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques

The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques
The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques

Sala Frigerio et al. show how microglia respond to amyloid-β, the Alzheimer's disease (AD)-causing factor. Their major response, the ARMs response, is enriched for AD risk genes, is abolished by Apoe deletion, develops faster in female mice, and is also part of normal aging. Thus, major AD risk factors converge on microglia.

Alzheimer, apoe, app knock in, ARM, in situ RNA hybridization, IRM, microglia, single cell RNA-seq, single cell sequencing
2211-1247
1293-1306.e6
Sala Frigerio, Carlo
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Wolfs, Leen
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Fattorelli, Nicola
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Thrupp, Nicola
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Voytyuk, Iryna
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Schmidt, Inga
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Mancuso, Renzo
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Chen, Wei Ting
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Woodbury, Maya E.
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Srivastava, Gyan
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Möller, Thomas
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Hudry, Eloise
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Das, Sudeshna
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Saido, Takaomi
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Karran, Eric
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Hyman, Bradley
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Perry, V. Hugh
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Fiers, Mark
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De Strooper, Bart
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Sala Frigerio, Carlo
ce10cc6f-db95-4c2a-af60-134ac468b829
Wolfs, Leen
cd49dd65-218b-4b13-944d-723f39233f3c
Fattorelli, Nicola
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Thrupp, Nicola
9f0abfe4-3ef9-49f8-b82a-1c64b4f62b47
Voytyuk, Iryna
73989040-59cd-4b3b-9ea4-3f91de87e004
Schmidt, Inga
1cf5af52-2ed9-49e0-a56c-628fbf1d8140
Mancuso, Renzo
05786562-a993-4e37-926e-3c1fcf50b36d
Chen, Wei Ting
de50faa9-563e-4e3f-9521-f9e67b671db6
Woodbury, Maya E.
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Srivastava, Gyan
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Möller, Thomas
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Hudry, Eloise
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Das, Sudeshna
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Saido, Takaomi
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Karran, Eric
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Hyman, Bradley
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Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Fiers, Mark
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De Strooper, Bart
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Sala Frigerio, Carlo, Wolfs, Leen, Fattorelli, Nicola, Thrupp, Nicola, Voytyuk, Iryna, Schmidt, Inga, Mancuso, Renzo, Chen, Wei Ting, Woodbury, Maya E., Srivastava, Gyan, Möller, Thomas, Hudry, Eloise, Das, Sudeshna, Saido, Takaomi, Karran, Eric, Hyman, Bradley, Perry, V. Hugh, Fiers, Mark and De Strooper, Bart (2019) The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques. Cell Reports, 27 (4), 1293-1306.e6. (doi:10.1016/j.celrep.2019.03.099).

Record type: Article

Abstract

Sala Frigerio et al. show how microglia respond to amyloid-β, the Alzheimer's disease (AD)-causing factor. Their major response, the ARMs response, is enriched for AD risk genes, is abolished by Apoe deletion, develops faster in female mice, and is also part of normal aging. Thus, major AD risk factors converge on microglia.

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Accepted/In Press date: 26 March 2019
Published date: 23 April 2019
Keywords: Alzheimer, apoe, app knock in, ARM, in situ RNA hybridization, IRM, microglia, single cell RNA-seq, single cell sequencing
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Identifiers

Local EPrints ID: 430526
URI: http://eprints.soton.ac.uk/id/eprint/430526
DOI: doi:10.1016/j.celrep.2019.03.099
ISSN: 2211-1247
PURE UUID: 17eb768d-7bd1-485c-a3c8-d2044d5a00e9

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Date deposited: 03 May 2019 16:30
Last modified: 05 Jun 2024 17:46

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Contributors

Author: Carlo Sala Frigerio
Author: Leen Wolfs
Author: Nicola Fattorelli
Author: Nicola Thrupp
Author: Iryna Voytyuk
Author: Inga Schmidt
Author: Renzo Mancuso
Author: Wei Ting Chen
Author: Maya E. Woodbury
Author: Gyan Srivastava
Author: Thomas Möller
Author: Eloise Hudry
Author: Sudeshna Das
Author: Takaomi Saido
Author: Eric Karran
Author: Bradley Hyman
Author: V. Hugh Perry
Author: Mark Fiers
Author: Bart De Strooper

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