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The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques

The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques
The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques

Sala Frigerio et al. show how microglia respond to amyloid-β, the Alzheimer's disease (AD)-causing factor. Their major response, the ARMs response, is enriched for AD risk genes, is abolished by Apoe deletion, develops faster in female mice, and is also part of normal aging. Thus, major AD risk factors converge on microglia.

Alzheimer, apoe, app knock in, ARM, in situ RNA hybridization, IRM, microglia, single cell RNA-seq, single cell sequencing
2211-1247
1293-1306.e6
Sala Frigerio, Carlo
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Wolfs, Leen
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Fattorelli, Nicola
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Thrupp, Nicola
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Voytyuk, Iryna
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Schmidt, Inga
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Mancuso, Renzo
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Chen, Wei Ting
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Woodbury, Maya E.
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Srivastava, Gyan
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Möller, Thomas
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Hudry, Eloise
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Das, Sudeshna
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Saido, Takaomi
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Karran, Eric
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Hyman, Bradley
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Perry, V. Hugh
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Fiers, Mark
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De Strooper, Bart
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Sala Frigerio, Carlo
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Wolfs, Leen
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Fattorelli, Nicola
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Thrupp, Nicola
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Voytyuk, Iryna
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Schmidt, Inga
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Mancuso, Renzo
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Chen, Wei Ting
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Woodbury, Maya E.
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Srivastava, Gyan
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Möller, Thomas
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Hudry, Eloise
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Das, Sudeshna
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Saido, Takaomi
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Karran, Eric
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Hyman, Bradley
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Perry, V. Hugh
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Fiers, Mark
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De Strooper, Bart
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Sala Frigerio, Carlo, Wolfs, Leen, Fattorelli, Nicola, Thrupp, Nicola, Voytyuk, Iryna, Schmidt, Inga, Mancuso, Renzo, Chen, Wei Ting, Woodbury, Maya E., Srivastava, Gyan, Möller, Thomas, Hudry, Eloise, Das, Sudeshna, Saido, Takaomi, Karran, Eric, Hyman, Bradley, Perry, V. Hugh, Fiers, Mark and De Strooper, Bart (2019) The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques. Cell Reports, 27 (4), 1293-1306.e6. (doi:10.1016/j.celrep.2019.03.099).

Record type: Article

Abstract

Sala Frigerio et al. show how microglia respond to amyloid-β, the Alzheimer's disease (AD)-causing factor. Their major response, the ARMs response, is enriched for AD risk genes, is abolished by Apoe deletion, develops faster in female mice, and is also part of normal aging. Thus, major AD risk factors converge on microglia.

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Accepted/In Press date: 26 March 2019
Published date: 23 April 2019
Keywords: Alzheimer, apoe, app knock in, ARM, in situ RNA hybridization, IRM, microglia, single cell RNA-seq, single cell sequencing

Identifiers

Local EPrints ID: 430526
URI: https://eprints.soton.ac.uk/id/eprint/430526
ISSN: 2211-1247
PURE UUID: 17eb768d-7bd1-485c-a3c8-d2044d5a00e9

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Date deposited: 03 May 2019 16:30
Last modified: 16 Sep 2019 16:33

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