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Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial

Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial
Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial

OBJECTIVES: To explore the effectiveness of a theory-based behavioral lifestyle intervention on health behaviors and quality of life in endometrial cancer survivors.' METHODS: This was a secondary analysis of a randomized controlled pilot trial conducted in two UK hospitals enrolling disease-free stage I-IVA endometrial cancer survivors. Participants were allocated to an 8-week group-based healthy eating and physical activity intervention or usual care using 1:1 minimization. Participants were followed up at 8 and 24 weeks, with the 8-week assessment being blinded. Diet, physical activity, and quality of life were measured with the Alternative Healthy Eating Index 2010, Stanford 7-Day Physical Activity Recall, and the EORTC Quality of life Questionnaire Core 30, respectively. We analyzed all eligible participants using the intention-to-treat approach in complete cases, adjusting for baseline values, body mass index, and age. RESULTS: We enrolled 60 of the 296 potentially eligible endometrial cancer survivors (May - December 2015). Fifty-four eligible participants were randomized to the intervention (n=29) or usual care (n=31), and 49 had complete follow-up data (n=24 in the intervention and n= 25 in usual care). Intervention adherence was 77%. At 8 weeks, participants in the intervention improved their diet compared to usual care (difference in Alternative Healthy Eating Index 2010 score 7.5 (95% CI: 0.1 to 14.9), P=0.046) but not their physical activity (0.1 metabolic equivalent-h/day 95% CI: (-1.6 to 1.8), P=0.879), or global quality of life score (5.0 (95% CI: -3.4 to 13.3), P=0.236). Global quality of life improved in intervention participants at 24 weeks (difference 8.9 (95% CI: 0.9 to 16.8), P=0.029). No intervention-related adverse events were reported. CONCLUSIONS: The potential effectiveness of the intervention appeared promising. A future fully-powered study is needed to confirm these findings. TRIAL REGISTRATION NUMBER: NCT02433080.

endometrial cancer, healthy eating, physical activity, quality of life
531-540
Koutoukidis, Dimitrios A.
603f46d3-9af7-45ec-92a7-d5d3d1cd7be9
Beeken, Rebecca J.
4700656e-38db-4836-9a37-9320e396566b
Manchanda, Ranjit
fcf99156-4522-406c-a935-f9885efb224c
Burnell, Matthew
54411b92-a8bc-4728-8959-a6667713cecd
Ziauddeen, Nida
3ad67dd8-26ba-498a-af0a-b1174298995b
Michalopoulou, Moscho
07f2e369-6b13-42e2-bb85-572fec7cf7d2
Knobf, M. Tish
43991586-35b6-4a49-a50d-c2ab0cc39b89
Lanceley, Anne
2b91cde8-7ce3-4f9d-bb6c-166e939ecf77
Koutoukidis, Dimitrios A.
603f46d3-9af7-45ec-92a7-d5d3d1cd7be9
Beeken, Rebecca J.
4700656e-38db-4836-9a37-9320e396566b
Manchanda, Ranjit
fcf99156-4522-406c-a935-f9885efb224c
Burnell, Matthew
54411b92-a8bc-4728-8959-a6667713cecd
Ziauddeen, Nida
3ad67dd8-26ba-498a-af0a-b1174298995b
Michalopoulou, Moscho
07f2e369-6b13-42e2-bb85-572fec7cf7d2
Knobf, M. Tish
43991586-35b6-4a49-a50d-c2ab0cc39b89
Lanceley, Anne
2b91cde8-7ce3-4f9d-bb6c-166e939ecf77

Koutoukidis, Dimitrios A., Beeken, Rebecca J., Manchanda, Ranjit, Burnell, Matthew, Ziauddeen, Nida, Michalopoulou, Moscho, Knobf, M. Tish and Lanceley, Anne (2019) Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial. International Journal of Gynecological Cancer, 29 (3), 531-540. (doi:10.1136/ijgc-2018-000039).

Record type: Article

Abstract

OBJECTIVES: To explore the effectiveness of a theory-based behavioral lifestyle intervention on health behaviors and quality of life in endometrial cancer survivors.' METHODS: This was a secondary analysis of a randomized controlled pilot trial conducted in two UK hospitals enrolling disease-free stage I-IVA endometrial cancer survivors. Participants were allocated to an 8-week group-based healthy eating and physical activity intervention or usual care using 1:1 minimization. Participants were followed up at 8 and 24 weeks, with the 8-week assessment being blinded. Diet, physical activity, and quality of life were measured with the Alternative Healthy Eating Index 2010, Stanford 7-Day Physical Activity Recall, and the EORTC Quality of life Questionnaire Core 30, respectively. We analyzed all eligible participants using the intention-to-treat approach in complete cases, adjusting for baseline values, body mass index, and age. RESULTS: We enrolled 60 of the 296 potentially eligible endometrial cancer survivors (May - December 2015). Fifty-four eligible participants were randomized to the intervention (n=29) or usual care (n=31), and 49 had complete follow-up data (n=24 in the intervention and n= 25 in usual care). Intervention adherence was 77%. At 8 weeks, participants in the intervention improved their diet compared to usual care (difference in Alternative Healthy Eating Index 2010 score 7.5 (95% CI: 0.1 to 14.9), P=0.046) but not their physical activity (0.1 metabolic equivalent-h/day 95% CI: (-1.6 to 1.8), P=0.879), or global quality of life score (5.0 (95% CI: -3.4 to 13.3), P=0.236). Global quality of life improved in intervention participants at 24 weeks (difference 8.9 (95% CI: 0.9 to 16.8), P=0.029). No intervention-related adverse events were reported. CONCLUSIONS: The potential effectiveness of the intervention appeared promising. A future fully-powered study is needed to confirm these findings. TRIAL REGISTRATION NUMBER: NCT02433080.

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More information

Accepted/In Press date: 31 August 2018
e-pub ahead of print date: 4 February 2019
Keywords: endometrial cancer, healthy eating, physical activity, quality of life

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Local EPrints ID: 430582
URI: http://eprints.soton.ac.uk/id/eprint/430582
PURE UUID: dddf0569-89dd-4b45-89c4-f6f34c258b40

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Date deposited: 03 May 2019 16:30
Last modified: 16 Mar 2024 01:01

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Contributors

Author: Dimitrios A. Koutoukidis
Author: Rebecca J. Beeken
Author: Ranjit Manchanda
Author: Matthew Burnell
Author: Nida Ziauddeen
Author: Moscho Michalopoulou
Author: M. Tish Knobf
Author: Anne Lanceley

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