X-ray microfocus Computed Tomography: a powerful tool for structural and functional characterisation of 3D printed dosage forms
X-ray microfocus Computed Tomography: a powerful tool for structural and functional characterisation of 3D printed dosage forms
One of the most promising advances in modern pharmaceutical technology is the introduction of three-dimensional (3D) printing technology for the fabrication of drug products. 3D printed dosage forms have the potential to revolutionize pharmacotherapy as streamlined production of structurally complex formulations with optimal drug releasing properties is now made possible. 3D printed formulations are derived as part of a process where a "print-head" deposits, or sinters material under computer control to produce a drug carrier. However, this manufacturing route inherently generates objects that deviate from the ideal designed template for reasons specific to the 3D printing method used. This short opinion article discusses the potential of high-resolution non-destructive 3D (volume) imaging by means of X-ray microfocus Computed Tomography (μCT) as a Process Analytical Technology for the structural and functional characterisation of 3D printed dosage forms.
X-ray microfocus Computed Tomography, μCT, 3D printing, Non-Destructive Testing (NDT)
Gioumouxouzis, Christos I
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Katsamenis, Orestis L
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Fatouros, Dimitrios G
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Gioumouxouzis, Christos I
6bbfb151-763a-48dc-8d1f-9cabd27c8d11
Katsamenis, Orestis L
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Fatouros, Dimitrios G
4a716c96-a8ba-4fbf-b3db-3b2a3a2794c4
Gioumouxouzis, Christos I, Katsamenis, Orestis L and Fatouros, Dimitrios G
(2019)
X-ray microfocus Computed Tomography: a powerful tool for structural and functional characterisation of 3D printed dosage forms.
Journal of Microscopy.
(doi:10.1111/jmi.12798).
Abstract
One of the most promising advances in modern pharmaceutical technology is the introduction of three-dimensional (3D) printing technology for the fabrication of drug products. 3D printed dosage forms have the potential to revolutionize pharmacotherapy as streamlined production of structurally complex formulations with optimal drug releasing properties is now made possible. 3D printed formulations are derived as part of a process where a "print-head" deposits, or sinters material under computer control to produce a drug carrier. However, this manufacturing route inherently generates objects that deviate from the ideal designed template for reasons specific to the 3D printing method used. This short opinion article discusses the potential of high-resolution non-destructive 3D (volume) imaging by means of X-ray microfocus Computed Tomography (μCT) as a Process Analytical Technology for the structural and functional characterisation of 3D printed dosage forms.
Text
GIOUMOUXOUZIS_et_al-2019-Journal_of_Microscopy
- Accepted Manuscript
More information
e-pub ahead of print date: 30 April 2019
Keywords:
X-ray microfocus Computed Tomography, μCT, 3D printing, Non-Destructive Testing (NDT)
Identifiers
Local EPrints ID: 430680
URI: http://eprints.soton.ac.uk/id/eprint/430680
ISSN: 0022-2720
PURE UUID: 4bdeea5f-0bec-415a-8033-ae8704d1163b
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Date deposited: 08 May 2019 16:30
Last modified: 16 Mar 2024 07:49
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Contributors
Author:
Christos I Gioumouxouzis
Author:
Dimitrios G Fatouros
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