Mittal, Vinita, Devitt, George, Bartlett, Philip N., Chong, Harold, Mashanovich, Goran, Mahajan, Sumeet and Wilkinson, James S (2019) Mid-infrared absorption spectroscopy of protein aggregates using germanium on silicon waveguides. In Proceedings of the European Conference on Integrated Optics 2019, Gent University, Ghent, Belgium. European Conference on Integrated Optics..
Abstract
Proteins in human samples can be used to detect the onset of a group of neurodegenerative diseases such as Alzheimer’s and Parkinson’s by studying their conformational (shape and structure) changes that can cause cognitive impairment. Proteins form aggregates from normal state (monomers) to disease state (amyloid deposition and fibril formation in central nervous system) that is associated with disease progression. These changes can be diagnosed and monitored using mid-infrared (MIR) absorption spectroscopy by studying line shapes and relative absorbance of amide bands. We have demonstrated MIR spectroscopy of proteins in three stages of aggregation: monomers, oligomers and fibrils of Bovine Serum Albumin (BSA) protein on a germanium on silicon (GOS) waveguide in the MIR wavelength region of 5.2 – 10 μm (1900 – 1000 cm-1). The protein samples were also characterised by atomic force microscopy to confirm their structure.
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- Current Faculties > Faculty of Engineering and Physical Sciences > School of Chemistry > Electrochemistry
School of Chemistry > Electrochemistry - Current Faculties > Faculty of Engineering and Physical Sciences > Zepler Institute for Photonics and Nanoelectronics > Nanophotonics Group > Photonic Systems Circuits and Sensors Group
Zepler Institute for Photonics and Nanoelectronics > Nanophotonics Group > Photonic Systems Circuits and Sensors Group - Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Institute for Life Sciences (pre 2018 reorg)
Current Faculties > Faculty of Environmental and Life Sciences > Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg)
Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg) - Current Faculties > Faculty of Engineering and Physical Sciences > School of Chemistry > Chemical Biology, Diagnostics and Therapeutics
School of Chemistry > Chemical Biology, Diagnostics and Therapeutics - Current Faculties > Faculty of Engineering and Physical Sciences > School of Electronics and Computer Science > Sustainable Electronic Technologies
School of Electronics and Computer Science > Sustainable Electronic Technologies - Current Faculties > Faculty of Environmental and Life Sciences > School of Biological Sciences > Neuroscience
School of Biological Sciences > Neuroscience
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