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Maternal plasma vitamin B12 concentrations during pregnancy and infant cognitive outcomes at 2 years of age

Maternal plasma vitamin B12 concentrations during pregnancy and infant cognitive outcomes at 2 years of age
Maternal plasma vitamin B12 concentrations during pregnancy and infant cognitive outcomes at 2 years of age

Evidence on long term influences of maternal vitamin B12 deficiency or concentrations on infant cognition is limited. We examined associations between maternal plasma vitamin B12 and cognitive development in 24-months old infants. Maternal plasma vitamin B12 concentrations were measured at 26-28 weeks' gestation; infant cognitive development assessed with the Bayley Scales of Infant and Toddler Development-III at 24 months, for 443 mother-infant pairs from the Growing Up in Singapore Towards healthy Outcomes cohort. Linear regressions adjusted for key confounders examined associations of maternal vitamin B12 with cognitive, receptive and expressive language, fine and gross motor subscales. Co-occurrence of maternal vitamin B12 with folate or vitamin B6 insufficiencies on child's cognition was explored. Average maternal plasma vitamin B12 concentrations was 220.5 ± 80.5 pmol/L; 15% and 41% of mothers were vitamin B12 deficient (<148pmol/L), and insufficient (148-220.9pmol/L) respectively. Infants of mothers with vitamin B12 deficiency had 0.42 SD (95% CI: â'0.70, -0.14 SD) lower cognitive scores, compared to infants of mothers with sufficient vitamin B12. Co-occurrence of maternal vitamins B12 and B6 insufficiencies was associated with 0.37 SD (95% CI: -0.69, -0.06 SD) lower cognitive scores in infants compared to infants of mothers sufficient in both vitamins. No significant associations were observed with other subscales. Study findings suggest possible need to ensure adequate vitamin B12 during pregnancy. The impact of co-occurrence of maternal B-vitamins insufficiencies on early cognitive development warrants further investigation.

Asian, cognition, infant, pregnancy, vitamin B12
0007-1145
Lai, Jun S.
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Mohamad Ayob, M. Na Im
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Cai, Shirong
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Quah, Phaik Ling
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Gluckman, Peter D.
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Shek, Lynette P.
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Yap, Fabian
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Tan, Kok Hian
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Chong, Yap Seng
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Godfrey, Keith M.
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Meaney, Michael J.
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Broekman, Birit F.P.
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Rifkin-Graboi, Anne
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Chong, Mary F.F.
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Lai, Jun S.
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Mohamad Ayob, M. Na Im
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Cai, Shirong
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Quah, Phaik Ling
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Gluckman, Peter D.
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Shek, Lynette P.
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Yap, Fabian
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Tan, Kok Hian
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Chong, Yap Seng
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Godfrey, Keith M.
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Meaney, Michael J.
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Broekman, Birit F.P.
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Rifkin-Graboi, Anne
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Chong, Mary F.F.
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Lai, Jun S., Mohamad Ayob, M. Na Im, Cai, Shirong, Quah, Phaik Ling, Gluckman, Peter D., Shek, Lynette P., Yap, Fabian, Tan, Kok Hian, Chong, Yap Seng, Godfrey, Keith M., Meaney, Michael J., Broekman, Birit F.P., Rifkin-Graboi, Anne and Chong, Mary F.F. (2019) Maternal plasma vitamin B12 concentrations during pregnancy and infant cognitive outcomes at 2 years of age. British Journal of Nutrition. (doi:10.1017/S0007114519000746).

Record type: Article

Abstract

Evidence on long term influences of maternal vitamin B12 deficiency or concentrations on infant cognition is limited. We examined associations between maternal plasma vitamin B12 and cognitive development in 24-months old infants. Maternal plasma vitamin B12 concentrations were measured at 26-28 weeks' gestation; infant cognitive development assessed with the Bayley Scales of Infant and Toddler Development-III at 24 months, for 443 mother-infant pairs from the Growing Up in Singapore Towards healthy Outcomes cohort. Linear regressions adjusted for key confounders examined associations of maternal vitamin B12 with cognitive, receptive and expressive language, fine and gross motor subscales. Co-occurrence of maternal vitamin B12 with folate or vitamin B6 insufficiencies on child's cognition was explored. Average maternal plasma vitamin B12 concentrations was 220.5 ± 80.5 pmol/L; 15% and 41% of mothers were vitamin B12 deficient (<148pmol/L), and insufficient (148-220.9pmol/L) respectively. Infants of mothers with vitamin B12 deficiency had 0.42 SD (95% CI: â'0.70, -0.14 SD) lower cognitive scores, compared to infants of mothers with sufficient vitamin B12. Co-occurrence of maternal vitamins B12 and B6 insufficiencies was associated with 0.37 SD (95% CI: -0.69, -0.06 SD) lower cognitive scores in infants compared to infants of mothers sufficient in both vitamins. No significant associations were observed with other subscales. Study findings suggest possible need to ensure adequate vitamin B12 during pregnancy. The impact of co-occurrence of maternal B-vitamins insufficiencies on early cognitive development warrants further investigation.

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maternal_plasma_vitamin_b12_concentrations_during_pregnancy_and_infant_cognitive_outcomes_at_2_years_of_age - Accepted Manuscript
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e-pub ahead of print date: 2 April 2019
Keywords: Asian, cognition, infant, pregnancy, vitamin B12

Identifiers

Local EPrints ID: 430890
URI: http://eprints.soton.ac.uk/id/eprint/430890
ISSN: 0007-1145
PURE UUID: 6662b0d0-114b-4faa-b600-8da7b62af3a4
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 17 May 2019 16:30
Last modified: 26 Nov 2021 05:21

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Contributors

Author: Jun S. Lai
Author: M. Na Im Mohamad Ayob
Author: Shirong Cai
Author: Phaik Ling Quah
Author: Peter D. Gluckman
Author: Lynette P. Shek
Author: Fabian Yap
Author: Kok Hian Tan
Author: Yap Seng Chong
Author: Michael J. Meaney
Author: Birit F.P. Broekman
Author: Anne Rifkin-Graboi
Author: Mary F.F. Chong

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