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Considerations for refining the risk assessment process for formaldehyde: results from an interdisciplinary workshop

Considerations for refining the risk assessment process for formaldehyde: results from an interdisciplinary workshop
Considerations for refining the risk assessment process for formaldehyde: results from an interdisciplinary workshop

Anticipating the need to evaluate and integrate scientific evidence to inform new risk assessments or to update existing risk assessments, the Formaldehyde Panel of the American Chemistry Council (ACC), in collaboration with the University of North Carolina, convened a workshop: “Understanding Potential Human Health Cancer Risk - From Data Integration to Risk Evaluation” in October 2017. Twenty-four (24)invited-experts participated with expertise in epidemiology, toxicology, science integration and risk evaluation. Including members of the organizing committee, there were 29 participants. The meeting included eleven presentations encompassing an introduction and three sessions: (1)“integrating the formaldehyde science on nasal/nasopharyngeal carcinogenicity and potential for causality”; (2)“integrating the formaldehyde science on lymphohematopoietic cancer and potential for causality; and, (3)“formaldehyde research-data suitable for risk assessment”. Here we describe key points from the presentations on epidemiology, toxicology and mechanistic studies that should inform decisions about the potential carcinogenicity of formaldehyde in humans and the discussions about approaches for structuring an integrated, comprehensive risk assessment for formaldehyde. We also note challenges expected when attempting to reconcile divergent results observed from research conducted within and across different scientific disciplines - especially toxicology and epidemiology - and in integrating diverse, multi-disciplinary mechanistic evidence.

Evidence integration, Formaldehyde, Inconsistent human epidemiology, Integrating data streams, Mode-of-action in animal studies, Reconciling conflicting conclusions
0273-2300
210-223
Andersen, Melvin E.
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Gentry, P. Robinan
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Swenberg, James A.
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Mundt, Kenneth A.
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White, Kimberly W.
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Thompson, Chad
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Bus, James
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Sherman, James H.
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Greim, Helmut
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Bolt, Hermann
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Marsh, Gary M.
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Checkoway, Harvey
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Coggon, David
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Clewell, Harvey J.
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Andersen, Melvin E.
44abcbc6-1612-4445-bf50-2a9eb4471399
Gentry, P. Robinan
020c3805-daaa-49be-be4d-a187c093e429
Swenberg, James A.
48799ea8-a944-4274-b207-2c4873434c25
Mundt, Kenneth A.
7502a563-3ea9-45f8-82c4-54fae8012038
White, Kimberly W.
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Thompson, Chad
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Bus, James
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Sherman, James H.
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Greim, Helmut
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Bolt, Hermann
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Marsh, Gary M.
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Checkoway, Harvey
318f7c21-189f-421d-9309-9f86f8a552af
Coggon, David
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Clewell, Harvey J.
d27befcf-2822-447b-ab42-5694477f1997

Andersen, Melvin E., Gentry, P. Robinan, Swenberg, James A., Mundt, Kenneth A., White, Kimberly W., Thompson, Chad, Bus, James, Sherman, James H., Greim, Helmut, Bolt, Hermann, Marsh, Gary M., Checkoway, Harvey, Coggon, David and Clewell, Harvey J. (2019) Considerations for refining the risk assessment process for formaldehyde: results from an interdisciplinary workshop. Regulatory Toxicology and Pharmacology, 106, 210-223. (doi:10.1016/j.yrtph.2019.04.015).

Record type: Article

Abstract

Anticipating the need to evaluate and integrate scientific evidence to inform new risk assessments or to update existing risk assessments, the Formaldehyde Panel of the American Chemistry Council (ACC), in collaboration with the University of North Carolina, convened a workshop: “Understanding Potential Human Health Cancer Risk - From Data Integration to Risk Evaluation” in October 2017. Twenty-four (24)invited-experts participated with expertise in epidemiology, toxicology, science integration and risk evaluation. Including members of the organizing committee, there were 29 participants. The meeting included eleven presentations encompassing an introduction and three sessions: (1)“integrating the formaldehyde science on nasal/nasopharyngeal carcinogenicity and potential for causality”; (2)“integrating the formaldehyde science on lymphohematopoietic cancer and potential for causality; and, (3)“formaldehyde research-data suitable for risk assessment”. Here we describe key points from the presentations on epidemiology, toxicology and mechanistic studies that should inform decisions about the potential carcinogenicity of formaldehyde in humans and the discussions about approaches for structuring an integrated, comprehensive risk assessment for formaldehyde. We also note challenges expected when attempting to reconcile divergent results observed from research conducted within and across different scientific disciplines - especially toxicology and epidemiology - and in integrating diverse, multi-disciplinary mechanistic evidence.

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Accepted/In Press date: 21 April 2019
e-pub ahead of print date: 3 May 2019
Published date: 1 August 2019
Keywords: Evidence integration, Formaldehyde, Inconsistent human epidemiology, Integrating data streams, Mode-of-action in animal studies, Reconciling conflicting conclusions

Identifiers

Local EPrints ID: 431125
URI: http://eprints.soton.ac.uk/id/eprint/431125
ISSN: 0273-2300
PURE UUID: e3101bc5-2543-4be3-8645-0ea4c951a05a
ORCID for David Coggon: ORCID iD orcid.org/0000-0003-1930-3987

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Date deposited: 24 May 2019 16:30
Last modified: 07 Oct 2020 01:39

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Contributors

Author: Melvin E. Andersen
Author: P. Robinan Gentry
Author: James A. Swenberg
Author: Kenneth A. Mundt
Author: Kimberly W. White
Author: Chad Thompson
Author: James Bus
Author: James H. Sherman
Author: Helmut Greim
Author: Hermann Bolt
Author: Gary M. Marsh
Author: Harvey Checkoway
Author: David Coggon ORCID iD
Author: Harvey J. Clewell

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