The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The redox architecture of physiological function

The redox architecture of physiological function
The redox architecture of physiological function
The ability of organisms to accommodate variations in metabolic need and environmental conditions is essential for their survival. However, an explanation is lacking as to how the necessary accommodations in response to these challenges are organized and coordinated from (sub)cellular to higher-level physiological functions, especially in mammals. We propose that the chemistry that enables coordination and synchronization of these processes dates to the origins of Life. We offer a conceptual framework based upon the nature of electron exchange (redox) processes that co-evolved with biological complexification, giving rise to a multi-layered system in which intra/intercellular and inter-organ exchange processes essential to sensing and adaptation stay fully synchronized. Our analysis explains why Redox is both the lingua franca and the mechanism that enable integration by connecting the various elements of regulatory processes. We here define these interactions across levels of organization as the ‘Redox Interactome’. This framework provides novel insight into the chemical and biological basis of redox signalling and may explain the recent convergence of metabolism, bioenergetics, and inflammation as well as the relationship between redox stress and human disease.
34-47
Santolini, Jerome
2e9403c4-40a3-4e49-bd50-916d01de14da
Wootton, Stephen A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Santolini, Jerome
2e9403c4-40a3-4e49-bd50-916d01de14da
Wootton, Stephen A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd

Santolini, Jerome, Wootton, Stephen A., Jackson, Alan A. and Feelisch, Martin (2019) The redox architecture of physiological function. Current Opinion in Physiology, 9, 34-47. (doi:10.1016/j.cophys.2019.04.009).

Record type: Review

Abstract

The ability of organisms to accommodate variations in metabolic need and environmental conditions is essential for their survival. However, an explanation is lacking as to how the necessary accommodations in response to these challenges are organized and coordinated from (sub)cellular to higher-level physiological functions, especially in mammals. We propose that the chemistry that enables coordination and synchronization of these processes dates to the origins of Life. We offer a conceptual framework based upon the nature of electron exchange (redox) processes that co-evolved with biological complexification, giving rise to a multi-layered system in which intra/intercellular and inter-organ exchange processes essential to sensing and adaptation stay fully synchronized. Our analysis explains why Redox is both the lingua franca and the mechanism that enable integration by connecting the various elements of regulatory processes. We here define these interactions across levels of organization as the ‘Redox Interactome’. This framework provides novel insight into the chemical and biological basis of redox signalling and may explain the recent convergence of metabolism, bioenergetics, and inflammation as well as the relationship between redox stress and human disease.

Text
1-s2.0-S2468867319300574-main - Version of Record
Available under License Creative Commons Attribution.
Download (1MB)

More information

Accepted/In Press date: 10 April 2019
e-pub ahead of print date: 19 April 2019
Published date: June 2019

Identifiers

Local EPrints ID: 431145
URI: http://eprints.soton.ac.uk/id/eprint/431145
PURE UUID: 67297b29-4862-4df3-a773-0478fe230867
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 24 May 2019 16:30
Last modified: 26 Nov 2021 02:58

Export record

Altmetrics

Contributors

Author: Jerome Santolini
Author: Alan A. Jackson
Author: Martin Feelisch ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×