The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Developmental trajectories of Body Mass Index from infancy to 18 years of age: prenatal determinants and health consequences

Developmental trajectories of Body Mass Index from infancy to 18 years of age: prenatal determinants and health consequences
Developmental trajectories of Body Mass Index from infancy to 18 years of age: prenatal determinants and health consequences

BACKGROUND: Knowledge on the long-term development of adiposity throughout childhood/adolescence and its prenatal determinants and health sequelae is lacking. We sought to (1) identify trajectories of Body Mass Index (BMI) from 1 to 18 years of age, (2) examine associations of maternal gestational smoking and early pregnancy overweight with offspring BMI trajectories and (3) determine whether BMI trajectories predict health outcomes: asthma, lung function parameters (forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio), and blood pressure, at 18 years.

METHODS: The Isle of Wight birth cohort, a population-based sample of 1456 infants born between January 1989 and February 1990, was prospectively assessed at ages 1, 2, 4, 10 and 18 years. Group-based trajectory modelling was applied to test for the presence of latent BMI trajectories. Associations were assessed using log-binomial and linear regression models.

RESULTS: Four trajectories of BMI were identified: 'normal', 'early persistent obesity', 'delayed overweight', and 'early transient overweight'. Risk factors for being in the early persistent obesity trajectory included maternal smoking during pregnancy (RR 2.16, 95% CI 1.02 to 4.68) and early pregnancy overweight (3.16, 1.52 to 6.58). When comparing the early persistent obesity to the normal trajectory, a 2.15-fold (1.33 to 3.49) increased risk of asthma, 3.2% (0.4% to 6.0%) deficit in FEV1/FVC ratio, and elevated systolic 11.3 mm Hg (7.1 to 15.4) and diastolic 12.0 mm Hg (8.9 to 15.1) blood pressure were observed at age 18 years.

CONCLUSIONS: Maternal prenatal exposures show prolonged effects on offspring's propensity towards overweight-obesity. Distinct morbid BMI trajectories are evident during the first 18 years of life that are associated with higher risk of asthma, reduced FEV1/FVC ratio, and elevated blood pressure.

Adolescent, Asthma/epidemiology, Body Mass Index, Child, Child, Preschool, Female, Humans, Hypertension/epidemiology, Infant, Male, Multivariate Analysis, Pediatric Obesity/epidemiology, Pregnancy, Pregnancy Trimester, First/physiology, Prenatal Exposure Delayed Effects, Pulmonary Ventilation/physiology, Smoking/adverse effects, United Kingdom/epidemiology, Weight Gain/physiology
0143-005X
934-941
Ziyab, Ali H.
12905e44-3fd1-47c2-98e5-35320e89815b
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Arshad, Syed Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Ziyab, Ali H.
12905e44-3fd1-47c2-98e5-35320e89815b
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Arshad, Syed Hasan
917e246d-2e60-472f-8d30-94b01ef28958

Ziyab, Ali H., Karmaus, Wilfried, Kurukulaaratchy, Ramesh J., Zhang, Hongmei and Arshad, Syed Hasan (2014) Developmental trajectories of Body Mass Index from infancy to 18 years of age: prenatal determinants and health consequences. Journal of Epidemiology and Community Health, 68 (10), 934-941. (doi:10.1136/jech-2014-203808).

Record type: Article

Abstract

BACKGROUND: Knowledge on the long-term development of adiposity throughout childhood/adolescence and its prenatal determinants and health sequelae is lacking. We sought to (1) identify trajectories of Body Mass Index (BMI) from 1 to 18 years of age, (2) examine associations of maternal gestational smoking and early pregnancy overweight with offspring BMI trajectories and (3) determine whether BMI trajectories predict health outcomes: asthma, lung function parameters (forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio), and blood pressure, at 18 years.

METHODS: The Isle of Wight birth cohort, a population-based sample of 1456 infants born between January 1989 and February 1990, was prospectively assessed at ages 1, 2, 4, 10 and 18 years. Group-based trajectory modelling was applied to test for the presence of latent BMI trajectories. Associations were assessed using log-binomial and linear regression models.

RESULTS: Four trajectories of BMI were identified: 'normal', 'early persistent obesity', 'delayed overweight', and 'early transient overweight'. Risk factors for being in the early persistent obesity trajectory included maternal smoking during pregnancy (RR 2.16, 95% CI 1.02 to 4.68) and early pregnancy overweight (3.16, 1.52 to 6.58). When comparing the early persistent obesity to the normal trajectory, a 2.15-fold (1.33 to 3.49) increased risk of asthma, 3.2% (0.4% to 6.0%) deficit in FEV1/FVC ratio, and elevated systolic 11.3 mm Hg (7.1 to 15.4) and diastolic 12.0 mm Hg (8.9 to 15.1) blood pressure were observed at age 18 years.

CONCLUSIONS: Maternal prenatal exposures show prolonged effects on offspring's propensity towards overweight-obesity. Distinct morbid BMI trajectories are evident during the first 18 years of life that are associated with higher risk of asthma, reduced FEV1/FVC ratio, and elevated blood pressure.

Text
934.full - Version of Record
Download (458kB)

More information

Accepted/In Press date: 15 May 2014
e-pub ahead of print date: 3 June 2014
Published date: October 2014
Keywords: Adolescent, Asthma/epidemiology, Body Mass Index, Child, Child, Preschool, Female, Humans, Hypertension/epidemiology, Infant, Male, Multivariate Analysis, Pediatric Obesity/epidemiology, Pregnancy, Pregnancy Trimester, First/physiology, Prenatal Exposure Delayed Effects, Pulmonary Ventilation/physiology, Smoking/adverse effects, United Kingdom/epidemiology, Weight Gain/physiology

Identifiers

Local EPrints ID: 431188
URI: http://eprints.soton.ac.uk/id/eprint/431188
ISSN: 0143-005X
PURE UUID: 3694655f-b960-4d6d-b8e6-222b0aa1abc5
ORCID for Ramesh J. Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400

Catalogue record

Date deposited: 24 May 2019 16:30
Last modified: 22 Nov 2021 02:44

Export record

Altmetrics

Contributors

Author: Ali H. Ziyab
Author: Wilfried Karmaus
Author: Hongmei Zhang

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×