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The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart

The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart
The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart

BACKGROUND: The aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.

METHODS: The FAIR birth cohort was established on the Isle of Wight (UK) between 2001 and 2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history.

RESULTS: In the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1, 2, 3 and 10 years, respectively. At 10 years of age, 12 of 828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first 10 years of life, 13 of 934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6 of 1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied.

CONCLUSION: Peanut allergy appears to be stable over the first 10 years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.

Allergens/immunology, Arachis/immunology, Child, Child, Preschool, Cohort Studies, Female, Humans, Immunoglobulin E/metabolism, Infant, Infant, Newborn, Male, Medical History Taking, Peanut Hypersensitivity/epidemiology, Prevalence, Prospective Studies, Skin Tests, Time Factors, United Kingdom/epidemiology
0905-6157
804-811
Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
Maslin, Kate
9d337ccf-5720-46b8-8bd1-fecb2f7ac2d1
Patil, Veeresh
25d44602-ebc7-4487-879a-c50500be203a
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Grundy, Jane
f8d6ced1-b9ab-4ee9-aa14-2f2805597fbe
Glasbey, Gillian
3554f23d-4709-4c2a-a972-2744f39fd7c8
Twiselton, Roger
639e0514-ff63-4623-ae1b-06f444cd14a9
Dean, Taraneh
c15c05ea-199c-4dc7-96cf-fdccdaafa41d
Arshad, Syed Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
Maslin, Kate
9d337ccf-5720-46b8-8bd1-fecb2f7ac2d1
Patil, Veeresh
25d44602-ebc7-4487-879a-c50500be203a
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Grundy, Jane
f8d6ced1-b9ab-4ee9-aa14-2f2805597fbe
Glasbey, Gillian
3554f23d-4709-4c2a-a972-2744f39fd7c8
Twiselton, Roger
639e0514-ff63-4623-ae1b-06f444cd14a9
Dean, Taraneh
c15c05ea-199c-4dc7-96cf-fdccdaafa41d
Arshad, Syed Hasan
917e246d-2e60-472f-8d30-94b01ef28958

Venter, Carina, Maslin, Kate, Patil, Veeresh, Kurukulaaratchy, Ramesh, Grundy, Jane, Glasbey, Gillian, Twiselton, Roger, Dean, Taraneh and Arshad, Syed Hasan (2016) The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatric Allergy and Immunology, 27 (8), 804-811. (doi:10.1111/pai.12616).

Record type: Article

Abstract

BACKGROUND: The aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.

METHODS: The FAIR birth cohort was established on the Isle of Wight (UK) between 2001 and 2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history.

RESULTS: In the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1, 2, 3 and 10 years, respectively. At 10 years of age, 12 of 828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first 10 years of life, 13 of 934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6 of 1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied.

CONCLUSION: Peanut allergy appears to be stable over the first 10 years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.

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More information

Accepted/In Press date: 16 July 2016
e-pub ahead of print date: 19 July 2016
Published date: December 2016
Keywords: Allergens/immunology, Arachis/immunology, Child, Child, Preschool, Cohort Studies, Female, Humans, Immunoglobulin E/metabolism, Infant, Infant, Newborn, Male, Medical History Taking, Peanut Hypersensitivity/epidemiology, Prevalence, Prospective Studies, Skin Tests, Time Factors, United Kingdom/epidemiology

Identifiers

Local EPrints ID: 431190
URI: http://eprints.soton.ac.uk/id/eprint/431190
ISSN: 0905-6157
PURE UUID: 0c26363a-7c4e-44a5-8e7c-5e19f74e88eb
ORCID for Ramesh Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400

Catalogue record

Date deposited: 24 May 2019 16:30
Last modified: 10 Nov 2021 02:58

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Contributors

Author: Carina Venter
Author: Kate Maslin
Author: Veeresh Patil
Author: Jane Grundy
Author: Gillian Glasbey
Author: Roger Twiselton
Author: Taraneh Dean

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