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EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis

EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis
EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis

The prevalence of allergic diseases such as allergic rhinitis, asthma, food allergy, and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures and lifestyle practices. The purpose of this review was to highlight the potential role for dietary fatty acids, in the prevention and management of these disorders. In addition to their nutritive value, fatty acids have important immunoregulatory effects. Fatty acid-associated biological mechanisms, human epidemiology, and intervention studies are summarized in this review. The influence of genetics and the microbiome on fatty acid metabolism is also discussed. Despite critical gaps in our current knowledge, it is increasingly apparent that dietary intake of fatty acids may influence the development of inflammatory and tolerogenic immune responses. However, the lack of standardized formats (ie, food versus supplement) and standardized doses, and frequently a lack of prestudy serum fatty acid level assessments in clinical studies significantly limit our ability to compare allergy outcomes across studies and to provide clear recommendations at this time. Future studies must address these limitations and individualized medical approaches should consider the inclusion of specific dietary factors for the prevention and management of asthma, food allergy, and atopic dermatitis.

0105-4538
Venter, Carina
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Meyer, Rosan W
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Nwaru, Bright I
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Roduit, Caroline
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Untersmayr, Eva
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Adel-Patient, Karine
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Agache, Ioana
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Agostoni, Carlo
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Akdis, Cezmi A
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Bischoff, Stephan
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du Toit, George
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Frei, Remo
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Garn, Holger
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Greenhawt, Matthew
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Renz, Harald
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Roberts, Graham C
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Renz, Harald
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Roberts, Graham C
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Smith, Peter
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Stanton, Catherine
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Vlieg-Boerstra, Berber
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Venter, Carina, Meyer, Rosan W, Nwaru, Bright I, Roduit, Caroline, Untersmayr, Eva, Adel-Patient, Karine, Agache, Ioana, Agostoni, Carlo, Akdis, Cezmi A, Bischoff, Stephan, du Toit, George, Feeney, Mary, Frei, Remo, Garn, Holger, Greenhawt, Matthew, Hoffmann-Sommergruber, Karin, Lunjani, Nonhlanhla, Maslin, Kate, Mills, Clare, Muraro, Antonella, Pali, Isabella, Poulson, Lars, Reese, Imke, Renz, Harald, Roberts, Graham C, Smith, Peter, Smolinska, Sylwia, Sokolowska, Milena, Stanton, Catherine, Vlieg-Boerstra, Berber and O'Mahony, Liam (2019) EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis. Allergy. (doi:10.1111/all.13764).

Record type: Article

Abstract

The prevalence of allergic diseases such as allergic rhinitis, asthma, food allergy, and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures and lifestyle practices. The purpose of this review was to highlight the potential role for dietary fatty acids, in the prevention and management of these disorders. In addition to their nutritive value, fatty acids have important immunoregulatory effects. Fatty acid-associated biological mechanisms, human epidemiology, and intervention studies are summarized in this review. The influence of genetics and the microbiome on fatty acid metabolism is also discussed. Despite critical gaps in our current knowledge, it is increasingly apparent that dietary intake of fatty acids may influence the development of inflammatory and tolerogenic immune responses. However, the lack of standardized formats (ie, food versus supplement) and standardized doses, and frequently a lack of prestudy serum fatty acid level assessments in clinical studies significantly limit our ability to compare allergy outcomes across studies and to provide clear recommendations at this time. Future studies must address these limitations and individualized medical approaches should consider the inclusion of specific dietary factors for the prevention and management of asthma, food allergy, and atopic dermatitis.

Text
Venter et al 2019 Allergy - Accepted Manuscript
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More information

Accepted/In Press date: 21 February 2019
e-pub ahead of print date: 29 April 2019

Identifiers

Local EPrints ID: 431199
URI: http://eprints.soton.ac.uk/id/eprint/431199
ISSN: 0105-4538
PURE UUID: 0d9b1fd9-f294-4bbf-9c96-d09c46250d8b
ORCID for Graham C Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 24 May 2019 16:30
Last modified: 10 Jan 2022 05:07

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Contributors

Author: Carina Venter
Author: Rosan W Meyer
Author: Bright I Nwaru
Author: Caroline Roduit
Author: Eva Untersmayr
Author: Karine Adel-Patient
Author: Ioana Agache
Author: Carlo Agostoni
Author: Cezmi A Akdis
Author: Stephan Bischoff
Author: George du Toit
Author: Mary Feeney
Author: Remo Frei
Author: Holger Garn
Author: Matthew Greenhawt
Author: Karin Hoffmann-Sommergruber
Author: Nonhlanhla Lunjani
Author: Kate Maslin
Author: Clare Mills
Author: Antonella Muraro
Author: Isabella Pali
Author: Lars Poulson
Author: Imke Reese
Author: Harald Renz
Author: Peter Smith
Author: Sylwia Smolinska
Author: Milena Sokolowska
Author: Catherine Stanton
Author: Berber Vlieg-Boerstra
Author: Liam O'Mahony

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