Nutritional modulation of the epigenome and its implication for future health
Nutritional modulation of the epigenome and its implication for future health
Non-communicable diseases (NCD) such as type-2 diabetes and CVD are now highly prevalent in both developed and developing countries. Evidence from both human and animal studies shows that early-life nutrition is an important determinant of NCD risk in later life. The mechanism by which the early-life environment influences future disease risk has been suggested to include the altered epigenetic regulation of gene expression. Epigenetic processes regulate the accessibility of genes to the cellular proteins that control gene transcription, determining where and when a gene is switched on and its level of activity. Epigenetic processes not only play a central role in regulating gene expression but also allow an organism to adapt to the environment. In this review, we will focus on how both maternal and paternal nutrition can alter the epigenome and the evidence that these changes are causally involved in determining future disease risk.
Biomarkers, Developmental origins of adult disease, DNA methylation, Epigenetics, Nutrition
1-8
Burton, Mark A.
250319ad-90dc-4651-b118-d5dbe5eaafa6
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Burton, Mark A.
250319ad-90dc-4651-b118-d5dbe5eaafa6
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Burton, Mark A. and Lillycrop, Karen A.
(2019)
Nutritional modulation of the epigenome and its implication for future health.
Proceedings of the Nutrition Society, .
(doi:10.1017/S0029665119000016).
Abstract
Non-communicable diseases (NCD) such as type-2 diabetes and CVD are now highly prevalent in both developed and developing countries. Evidence from both human and animal studies shows that early-life nutrition is an important determinant of NCD risk in later life. The mechanism by which the early-life environment influences future disease risk has been suggested to include the altered epigenetic regulation of gene expression. Epigenetic processes regulate the accessibility of genes to the cellular proteins that control gene transcription, determining where and when a gene is switched on and its level of activity. Epigenetic processes not only play a central role in regulating gene expression but also allow an organism to adapt to the environment. In this review, we will focus on how both maternal and paternal nutrition can alter the epigenome and the evidence that these changes are causally involved in determining future disease risk.
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e-pub ahead of print date: 19 February 2019
Keywords:
Biomarkers, Developmental origins of adult disease, DNA methylation, Epigenetics, Nutrition
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Local EPrints ID: 431207
URI: http://eprints.soton.ac.uk/id/eprint/431207
ISSN: 0029-6651
PURE UUID: 193d0b4b-49ce-4e70-beb5-d6a766c3f4a0
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Date deposited: 24 May 2019 16:30
Last modified: 11 Jul 2024 01:58
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