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Chip-based resonance Raman spectroscopy using tantalum pentoxide waveguides

Chip-based resonance Raman spectroscopy using tantalum pentoxide waveguides
Chip-based resonance Raman spectroscopy using tantalum pentoxide waveguides
Blood analysis is an important diagnostic tool, as it provides a wealth of information about the patient’s health. Raman spectroscopy is a promising tool in blood analysis, but widespread clinical application is limited by its low signal strength, as well as complex and costly instrumentation. The growing field of waveguide-based Raman spectroscopy tries to solve these challenges by working towards fully integrated Raman sensors with increased interaction areas. In this work, we demonstrate resonance Raman measurements of hemoglobin, a crucial component of blood, at 532 nm excitation using a tantalum pentoxide (Ta2O5) waveguide platform. We have also characterized the background signal from Ta2O5 waveguide material when excited at 532 nm. In addition, we demonstrate spontaneous Raman measurements of iso-propanol and methanol using the same platform. Our results suggest that Ta2O5 is a promising waveguide platform for resonance Raman spectroscopy at 532 nm, and in particular for blood analysis.
1041-1135
1127-1130
Coucheron, David
350eac59-d6ba-4c0a-90cd-658fcf9376e1
Wadduwage, Dushan
7acfcca1-a58c-42c4-a97b-c1d4c43bdb35
Murugan, Ganapathy Senthil
a867686e-0535-46cc-ad85-c2342086b25b
So, Peter
a40361af-54b7-422b-a7d2-ea9c992540f1
Ahluwalia, Balpreet Singh
f6dfb1bb-760f-4a7e-9050-d66de72348e0
Coucheron, David
350eac59-d6ba-4c0a-90cd-658fcf9376e1
Wadduwage, Dushan
7acfcca1-a58c-42c4-a97b-c1d4c43bdb35
Murugan, Ganapathy Senthil
a867686e-0535-46cc-ad85-c2342086b25b
So, Peter
a40361af-54b7-422b-a7d2-ea9c992540f1
Ahluwalia, Balpreet Singh
f6dfb1bb-760f-4a7e-9050-d66de72348e0

Coucheron, David, Wadduwage, Dushan, Murugan, Ganapathy Senthil, So, Peter and Ahluwalia, Balpreet Singh (2019) Chip-based resonance Raman spectroscopy using tantalum pentoxide waveguides. IEEE Photonics Technology Letters, 31 (14), 1127-1130, [8709965]. (doi:10.1109/LPT.2019.2915671).

Record type: Article

Abstract

Blood analysis is an important diagnostic tool, as it provides a wealth of information about the patient’s health. Raman spectroscopy is a promising tool in blood analysis, but widespread clinical application is limited by its low signal strength, as well as complex and costly instrumentation. The growing field of waveguide-based Raman spectroscopy tries to solve these challenges by working towards fully integrated Raman sensors with increased interaction areas. In this work, we demonstrate resonance Raman measurements of hemoglobin, a crucial component of blood, at 532 nm excitation using a tantalum pentoxide (Ta2O5) waveguide platform. We have also characterized the background signal from Ta2O5 waveguide material when excited at 532 nm. In addition, we demonstrate spontaneous Raman measurements of iso-propanol and methanol using the same platform. Our results suggest that Ta2O5 is a promising waveguide platform for resonance Raman spectroscopy at 532 nm, and in particular for blood analysis.

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Accepted/In Press date: 30 April 2019
e-pub ahead of print date: 8 May 2019
Published date: 15 July 2019

Identifiers

Local EPrints ID: 431239
URI: http://eprints.soton.ac.uk/id/eprint/431239
ISSN: 1041-1135
PURE UUID: e91d5354-78ff-4a3c-85ae-927e69d4c29e
ORCID for Ganapathy Senthil Murugan: ORCID iD orcid.org/0000-0002-2733-3273

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Date deposited: 28 May 2019 16:30
Last modified: 18 Feb 2021 17:05

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