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Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study

Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study
Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study

Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25-75% (FEF25-75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early life risk factors before the age of 10 years were assessed for the trajectories.

METHOD: Members of the birth cohort (1989/90) were followed at age 1, 2, 4, 10, 18, and 26 years. Allergic sensitization and questionnaire data were collected. Spirometry tests were performed and evaluated according to the American Thoracic Society (ATS) criteria at 10, 18, and 26 years. To identify developmental trajectories for FVC, FEV1, FEV1/FVC, and FEF25-75 from 10 to 26 years, a finite mixture model was applied to the longitudinal lung function data, separately for males and females. Associations of early life factors with the respective lung function trajectories were assessed using log-linear and logistic regression analyses.

RESULTS: Both high and low lung function trajectories were observed in men and women. FVC continued to grow beyond 18 years in men and women, whereas FEV1 peaked at age 18 years in female trajectories and in one male trajectory. For the FEV1/FVC ratios and FEF25-75 most trajectories appeared highest at age 18 and declined thereafter. However, the low FEV1/FVC trajectory in both sexes showed an early decline at 10 years. Lower birth weight was linked with lower lung function trajectories in males and females. Eczema in the first year of life was a risk factor for later lung function deficits in females, whereas the occurrence of asthma at 4 years of age was a risk factor for later lung function deficits in males. A positive skin prick test at age four was a risk for the low FEV1 trajectory in females and for the low FEV1/FVC trajectory in males.

CONCLUSION: Men and women showed distinctive lung function trajectories and associated risk factors. Lower lung function trajectories can be explained by not achieving maximally attainable function at age 18 years and by a function decline from 18 to 26 years.

1465-9921
1-13
Karmaus, Wilfried
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Mukherjee, Nandini
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Janjanam, Vimala Devi
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Chen, Su
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Zhang, Hongmei
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Roberts, Graham
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Kurukulaaratchy, Ramesh J
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Arshad, Hasan
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Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Mukherjee, Nandini
f64f02d6-2fd0-40db-88ee-5f85b59b8e0b
Janjanam, Vimala Devi
62f16860-3d75-4efc-b6b6-2a3a88549a85
Chen, Su
ffb45732-4c5d-4329-afa3-9cab1c38fd1c
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Kurukulaaratchy, Ramesh J
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Arshad, Hasan
917e246d-2e60-472f-8d30-94b01ef28958

Karmaus, Wilfried, Mukherjee, Nandini, Janjanam, Vimala Devi, Chen, Su, Zhang, Hongmei, Roberts, Graham, Kurukulaaratchy, Ramesh J and Arshad, Hasan (2019) Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study. Respiratory Research, 20 (1), 1-13. (doi:10.1186/s12931-019-1068-0).

Record type: Article

Abstract

Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25-75% (FEF25-75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early life risk factors before the age of 10 years were assessed for the trajectories.

METHOD: Members of the birth cohort (1989/90) were followed at age 1, 2, 4, 10, 18, and 26 years. Allergic sensitization and questionnaire data were collected. Spirometry tests were performed and evaluated according to the American Thoracic Society (ATS) criteria at 10, 18, and 26 years. To identify developmental trajectories for FVC, FEV1, FEV1/FVC, and FEF25-75 from 10 to 26 years, a finite mixture model was applied to the longitudinal lung function data, separately for males and females. Associations of early life factors with the respective lung function trajectories were assessed using log-linear and logistic regression analyses.

RESULTS: Both high and low lung function trajectories were observed in men and women. FVC continued to grow beyond 18 years in men and women, whereas FEV1 peaked at age 18 years in female trajectories and in one male trajectory. For the FEV1/FVC ratios and FEF25-75 most trajectories appeared highest at age 18 and declined thereafter. However, the low FEV1/FVC trajectory in both sexes showed an early decline at 10 years. Lower birth weight was linked with lower lung function trajectories in males and females. Eczema in the first year of life was a risk factor for later lung function deficits in females, whereas the occurrence of asthma at 4 years of age was a risk factor for later lung function deficits in males. A positive skin prick test at age four was a risk for the low FEV1 trajectory in females and for the low FEV1/FVC trajectory in males.

CONCLUSION: Men and women showed distinctive lung function trajectories and associated risk factors. Lower lung function trajectories can be explained by not achieving maximally attainable function at age 18 years and by a function decline from 18 to 26 years.

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Accepted/In Press date: 6 May 2019
Published date: 22 May 2019

Identifiers

Local EPrints ID: 431276
URI: http://eprints.soton.ac.uk/id/eprint/431276
ISSN: 1465-9921
PURE UUID: cf8703d8-5788-4aab-83e0-0f4ceb4d9ba4
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248
ORCID for Ramesh J Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400

Catalogue record

Date deposited: 29 May 2019 16:30
Last modified: 22 Nov 2021 02:52

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Contributors

Author: Wilfried Karmaus
Author: Nandini Mukherjee
Author: Vimala Devi Janjanam
Author: Su Chen
Author: Hongmei Zhang
Author: Graham Roberts ORCID iD
Author: Hasan Arshad

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