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Inhibition of the synthesis and secretion of extracellular glucosyl- and fructosyltransferase in Streptococcus sanguis by sodium ions

Inhibition of the synthesis and secretion of extracellular glucosyl- and fructosyltransferase in Streptococcus sanguis by sodium ions
Inhibition of the synthesis and secretion of extracellular glucosyl- and fructosyltransferase in Streptococcus sanguis by sodium ions
The influence of Na+ and K+ on the synthesis and secretion of extracellular glucosyltransferase (GTF; EC 2.4.1.5) and fructosyltransferase (FTF; EC 2.4.1.10) by Streptococcus sanguis NCTC 7865 and Streptococcus sanguis Challis NCTC 7868 has been determined. No FTF and little or no mutansucrase (GTF-I) activities were detectable during growth on glucose or sucrose unless the Na+/K+ ratio of the cultures was kept low. Increasing K+ concentrations stimulated the production of FTF and dextransucrase (GTF-S), but all glycosyltransferase activities decreased in high K+ media when the growth pH was maintained with NaOH instead of KOH, indicating that the Na+/K+ ratio effect was due principally to Na+ inhibition. Significant GTF and FTF activities were detected in a putative GTF- mutant of strain Challis grown in high K+ medium but not in high Na+ medium, suggesting that the mutant might be defective in a regulatory gene.
0022-1287
77-82
Keevil, C. W.
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
West, A. A.
5f1b2798-9f0f-4e4b-875c-bec8bab6b820
Bourne, N.
f61250e3-16df-403e-9f97-ac2aa746ecff
Marsh, P. D.
9d226405-bfd2-432b-ac22-ea619f706805
Keevil, C. W.
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
West, A. A.
5f1b2798-9f0f-4e4b-875c-bec8bab6b820
Bourne, N.
f61250e3-16df-403e-9f97-ac2aa746ecff
Marsh, P. D.
9d226405-bfd2-432b-ac22-ea619f706805

Keevil, C. W., West, A. A., Bourne, N. and Marsh, P. D. (1984) Inhibition of the synthesis and secretion of extracellular glucosyl- and fructosyltransferase in Streptococcus sanguis by sodium ions. Journal of General Microbiology, 130 (1), 77-82. (doi:10.1099/00221287-130-1-77).

Record type: Article

Abstract

The influence of Na+ and K+ on the synthesis and secretion of extracellular glucosyltransferase (GTF; EC 2.4.1.5) and fructosyltransferase (FTF; EC 2.4.1.10) by Streptococcus sanguis NCTC 7865 and Streptococcus sanguis Challis NCTC 7868 has been determined. No FTF and little or no mutansucrase (GTF-I) activities were detectable during growth on glucose or sucrose unless the Na+/K+ ratio of the cultures was kept low. Increasing K+ concentrations stimulated the production of FTF and dextransucrase (GTF-S), but all glycosyltransferase activities decreased in high K+ media when the growth pH was maintained with NaOH instead of KOH, indicating that the Na+/K+ ratio effect was due principally to Na+ inhibition. Significant GTF and FTF activities were detected in a putative GTF- mutant of strain Challis grown in high K+ medium but not in high Na+ medium, suggesting that the mutant might be defective in a regulatory gene.

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Published date: 1 January 1984

Identifiers

Local EPrints ID: 431309
URI: http://eprints.soton.ac.uk/id/eprint/431309
ISSN: 0022-1287
PURE UUID: a146a393-0e66-44cd-9a14-c34327eec691
ORCID for C. W. Keevil: ORCID iD orcid.org/0000-0003-1917-7706

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Date deposited: 29 May 2019 16:30
Last modified: 16 Mar 2024 03:24

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Contributors

Author: C. W. Keevil ORCID iD
Author: A. A. West
Author: N. Bourne
Author: P. D. Marsh

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