Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis
Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis
The effect of 0.07 or 0.15 mMchlorhexidine (CHX) and 4.0 or 8.0 mM potassium fluoride (F), added singly and in combinations, on acid production by Streptococcus mutans and Streptococcus sanguis was studied. Cells were grown in a chemostat under different environmental conditions and acid production from glucose or sucrose was measured as a rate at pH 7.0 and by pH-fall experiments. CHX had a greater inhibitory action on S. mutans while S. sanguis was more sensitive to F. Growth conditions affected the sensitivity of both strains to the two inhibitors and, in general, cells grown glucose-limited were the most sensitive. Combinations of F and CHX showed additive inhibitory effects on acid production, irrespective of the method of measurement.
Acid production, bacterial, Chlorhexidine, Fluoride, Streptococcus mutans, Streptococcus sanguis
64-71
McDermid, Ann S.
34686047-11ba-41da-884d-1dc41fa7024b
Marsh, P. D.
9d226405-bfd2-432b-ac22-ea619f706805
Keevil, C. W.
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
Ellwood, D. C.
a7dc8f2a-f392-42b4-a022-fa5a58cf6be6
1985
McDermid, Ann S.
34686047-11ba-41da-884d-1dc41fa7024b
Marsh, P. D.
9d226405-bfd2-432b-ac22-ea619f706805
Keevil, C. W.
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
Ellwood, D. C.
a7dc8f2a-f392-42b4-a022-fa5a58cf6be6
McDermid, Ann S., Marsh, P. D., Keevil, C. W. and Ellwood, D. C.
(1985)
Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis.
Caries Research, 19 (1), .
(doi:10.1159/000260830).
Abstract
The effect of 0.07 or 0.15 mMchlorhexidine (CHX) and 4.0 or 8.0 mM potassium fluoride (F), added singly and in combinations, on acid production by Streptococcus mutans and Streptococcus sanguis was studied. Cells were grown in a chemostat under different environmental conditions and acid production from glucose or sucrose was measured as a rate at pH 7.0 and by pH-fall experiments. CHX had a greater inhibitory action on S. mutans while S. sanguis was more sensitive to F. Growth conditions affected the sensitivity of both strains to the two inhibitors and, in general, cells grown glucose-limited were the most sensitive. Combinations of F and CHX showed additive inhibitory effects on acid production, irrespective of the method of measurement.
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Published date: 1985
Keywords:
Acid production, bacterial, Chlorhexidine, Fluoride, Streptococcus mutans, Streptococcus sanguis
Identifiers
Local EPrints ID: 431316
URI: http://eprints.soton.ac.uk/id/eprint/431316
ISSN: 0008-6568
PURE UUID: b5e9adee-a4d8-4f03-8006-294d457091de
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Date deposited: 29 May 2019 16:30
Last modified: 06 Jun 2024 01:40
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Author:
Ann S. McDermid
Author:
P. D. Marsh
Author:
D. C. Ellwood
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