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Acquired immune responses to the seasonal trivalent influenza vaccination in COPD

Acquired immune responses to the seasonal trivalent influenza vaccination in COPD
Acquired immune responses to the seasonal trivalent influenza vaccination in COPD
Epidemiological data suggests that influenza vaccination protects against all-cause mortality in COPD patients. However recent work has suggested there is a defect in the ability of some COPD patients to mount an adequate humoral response to influenza vaccination. The aim of our study was to investigate humoral and cell mediated vaccine responses to the seasonal trivalent influenza vaccination (TIV), in COPD subjects and healthy controls. 47 subjects were enrolled into the study; 23 COPD patients, 13 age-matched healthy control (HC - ≥50) and 11 young healthy control subjects (YC - ≤40). Serum and PBMC were isolated pre-TIV vaccination and at days 7, 28 and 6 months post vaccine for Haemagglutinin Inhibition (HAI) titre, antigen-specific T cell and antibody-secreting cell analysis. The kinetics of the vaccine response were similar between YC, HC and COPD patients and there was no significant difference in antibody titres between these groups 28d post-vaccine. As we observed no disease-dependent differences in either humoral or cellular responses, we investigated if there was any association of these measures with age. H1N1 (r=-0.4253, p=0.0036) and Influenza B (r=-0.344, p=0.0192) antibody titre at 28d negatively correlated with age as did H1N1-specific CD4+ T helper cells (r=-0.4276, p=0.0034). These results suggest that age is the primary determinant of response to trivalent vaccine and that COPD is not a driver of deficient responses per se. These data support the continued use of the yearly trivalent vaccine as an adjunct to COPD disease management.
COPD, influenza, vaccination
1365-2249
71-82
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
Williams, Nicholas P.
00ee9f78-fdc9-434f-be3e-5ded7a8abe08
Bonduelle, Olivia
d5177db8-0b4b-4c99-a1da-f17d6bfbeec1
Hutton, Andrew J.
1b19a9ff-f942-4e5a-a2ff-62e2c84d2328
Cellura, Doriana
e4cffc4c-0e12-40e7-ad13-e90e3fb55332
Marriott, Anthony C.
0e243190-65cb-4ab7-b2dd-5afc32051a94
Combadière, Béhazine
6f978793-4faf-4cba-b57a-da81e173ecd3
Wilkinson, Tom M.A.
8c55ebbb-e547-445c-95a1-c8bed02dd652
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
Williams, Nicholas P.
00ee9f78-fdc9-434f-be3e-5ded7a8abe08
Bonduelle, Olivia
d5177db8-0b4b-4c99-a1da-f17d6bfbeec1
Hutton, Andrew J.
1b19a9ff-f942-4e5a-a2ff-62e2c84d2328
Cellura, Doriana
e4cffc4c-0e12-40e7-ad13-e90e3fb55332
Marriott, Anthony C.
0e243190-65cb-4ab7-b2dd-5afc32051a94
Combadière, Béhazine
6f978793-4faf-4cba-b57a-da81e173ecd3
Wilkinson, Tom M.A.
8c55ebbb-e547-445c-95a1-c8bed02dd652

Staples, Karl J., Williams, Nicholas P., Bonduelle, Olivia, Hutton, Andrew J., Cellura, Doriana, Marriott, Anthony C., Combadière, Béhazine and Wilkinson, Tom M.A. (2019) Acquired immune responses to the seasonal trivalent influenza vaccination in COPD. Clinical and Experimental Immunology, 198 (1), 71-82. (doi:10.1111/cei.13336).

Record type: Article

Abstract

Epidemiological data suggests that influenza vaccination protects against all-cause mortality in COPD patients. However recent work has suggested there is a defect in the ability of some COPD patients to mount an adequate humoral response to influenza vaccination. The aim of our study was to investigate humoral and cell mediated vaccine responses to the seasonal trivalent influenza vaccination (TIV), in COPD subjects and healthy controls. 47 subjects were enrolled into the study; 23 COPD patients, 13 age-matched healthy control (HC - ≥50) and 11 young healthy control subjects (YC - ≤40). Serum and PBMC were isolated pre-TIV vaccination and at days 7, 28 and 6 months post vaccine for Haemagglutinin Inhibition (HAI) titre, antigen-specific T cell and antibody-secreting cell analysis. The kinetics of the vaccine response were similar between YC, HC and COPD patients and there was no significant difference in antibody titres between these groups 28d post-vaccine. As we observed no disease-dependent differences in either humoral or cellular responses, we investigated if there was any association of these measures with age. H1N1 (r=-0.4253, p=0.0036) and Influenza B (r=-0.344, p=0.0192) antibody titre at 28d negatively correlated with age as did H1N1-specific CD4+ T helper cells (r=-0.4276, p=0.0034). These results suggest that age is the primary determinant of response to trivalent vaccine and that COPD is not a driver of deficient responses per se. These data support the continued use of the yearly trivalent vaccine as an adjunct to COPD disease management.

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Staples et al TRICS paper 2019-05-09 - Accepted Manuscript
Restricted to Repository staff only until 29 May 2020.
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Accepted/In Press date: 29 May 2019
e-pub ahead of print date: 17 June 2019
Published date: October 2019
Keywords: COPD, influenza, vaccination

Identifiers

Local EPrints ID: 431524
URI: https://eprints.soton.ac.uk/id/eprint/431524
ISSN: 1365-2249
PURE UUID: 3f996656-9c68-403a-87ca-0eafd6864ba4
ORCID for Karl J. Staples: ORCID iD orcid.org/0000-0003-3844-6457

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Date deposited: 07 Jun 2019 16:30
Last modified: 05 Nov 2019 01:46

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Contributors

Author: Karl J. Staples ORCID iD
Author: Nicholas P. Williams
Author: Olivia Bonduelle
Author: Andrew J. Hutton
Author: Doriana Cellura
Author: Anthony C. Marriott
Author: Béhazine Combadière

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