The University of Southampton
University of Southampton Institutional Repository

Performance of carbon nano-scale allotropes in detecting midazolam and paracetamol in undiluted human serum

Performance of carbon nano-scale allotropes in detecting midazolam and paracetamol in undiluted human serum
Performance of carbon nano-scale allotropes in detecting midazolam and paracetamol in undiluted human serum

Nano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the electro-active surface area (EASA). In this paper, an analytical calculation of the deposited EASA is presented and experimentally validated by comparing two kinds of nano-structured electrochemical sensors modified with multi-walled carbon nano-tubes (MWCNTs) and fullerenes. Further, the two differently nano-structured electrodes, prepared with equal optimum EASA, have been adopted as novel approach in the detection of paracetamol (APAP) and midazolam (MZ), two largely adopted and complementary sedative drugs. We have used the novel approach to let emerge the different nano-scale structures' sensing performance at the same equivalent EASA. The analytical method for EASA calculation has been recently validated by our group on different nano-materials; hence the aim of the actual work is to present, for the first time, its efficient applicability also in comparing the performance of different allotropes of the same nature (carbon-based) in drug sensing, e.g., MZ and APAP. This paper also includes the comparison in undiluted human serum (HS), proposed here as complex bio-sample, to confirm the validity of our novel approach close to real applications. With respect to fullerenes, the MWCNTs-modified electrodes obtained the best limit of detection values in HS detection, as 0.3518 \mu \text{M} and 0.5367 mm for APAP and MZ, respectively. Scanning electron microscopy analysis also confirmed the higher quality of MWCNTs-based surface in terms of homogeneity and denser coverage of the surface with respect to fullerene-based one, with a better-packed aggregate of assembled structures.

Anesthetics, EASA, electrochemistry, human serum, nano-structured electrodes
1530-437X
5073-5081
Aliakbarinodehi, Nima
026ccbe6-5e6d-4eff-99f4-78b718e60b19
Stradolini, Francesca
46dd9a7e-6b60-4c41-8950-f51febd8ca13
Nakhjavani, Sattar Akbari
8c29b8b5-039a-445e-82e6-8af924fe4e9e
Tzouvadaki, Ioulia
a1025ec1-7606-453d-bc71-1f732a4c1f78
Taurino, Irene
d0a3e3a5-10d1-4619-add0-2a98a3e12ebc
De Micheli, Giovanni
23af8e38-a795-4edf-b551-9094fdb781e0
Carrara, Sandro
0001b4c5-1f62-4789-b0e9-5a187f58b893
Aliakbarinodehi, Nima
026ccbe6-5e6d-4eff-99f4-78b718e60b19
Stradolini, Francesca
46dd9a7e-6b60-4c41-8950-f51febd8ca13
Nakhjavani, Sattar Akbari
8c29b8b5-039a-445e-82e6-8af924fe4e9e
Tzouvadaki, Ioulia
a1025ec1-7606-453d-bc71-1f732a4c1f78
Taurino, Irene
d0a3e3a5-10d1-4619-add0-2a98a3e12ebc
De Micheli, Giovanni
23af8e38-a795-4edf-b551-9094fdb781e0
Carrara, Sandro
0001b4c5-1f62-4789-b0e9-5a187f58b893

Aliakbarinodehi, Nima, Stradolini, Francesca, Nakhjavani, Sattar Akbari, Tzouvadaki, Ioulia, Taurino, Irene, De Micheli, Giovanni and Carrara, Sandro (2018) Performance of carbon nano-scale allotropes in detecting midazolam and paracetamol in undiluted human serum. IEEE Sensors Journal, 18 (12), 5073-5081. (doi:10.1109/JSEN.2018.2828416).

Record type: Article

Abstract

Nano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the electro-active surface area (EASA). In this paper, an analytical calculation of the deposited EASA is presented and experimentally validated by comparing two kinds of nano-structured electrochemical sensors modified with multi-walled carbon nano-tubes (MWCNTs) and fullerenes. Further, the two differently nano-structured electrodes, prepared with equal optimum EASA, have been adopted as novel approach in the detection of paracetamol (APAP) and midazolam (MZ), two largely adopted and complementary sedative drugs. We have used the novel approach to let emerge the different nano-scale structures' sensing performance at the same equivalent EASA. The analytical method for EASA calculation has been recently validated by our group on different nano-materials; hence the aim of the actual work is to present, for the first time, its efficient applicability also in comparing the performance of different allotropes of the same nature (carbon-based) in drug sensing, e.g., MZ and APAP. This paper also includes the comparison in undiluted human serum (HS), proposed here as complex bio-sample, to confirm the validity of our novel approach close to real applications. With respect to fullerenes, the MWCNTs-modified electrodes obtained the best limit of detection values in HS detection, as 0.3518 \mu \text{M} and 0.5367 mm for APAP and MZ, respectively. Scanning electron microscopy analysis also confirmed the higher quality of MWCNTs-based surface in terms of homogeneity and denser coverage of the surface with respect to fullerene-based one, with a better-packed aggregate of assembled structures.

Full text not available from this repository.

More information

Accepted/In Press date: 16 April 2018
e-pub ahead of print date: 20 April 2018
Published date: 15 June 2018
Keywords: Anesthetics, EASA, electrochemistry, human serum, nano-structured electrodes

Identifiers

Local EPrints ID: 431542
URI: http://eprints.soton.ac.uk/id/eprint/431542
ISSN: 1530-437X
PURE UUID: 4d973df9-fa05-41bc-b2fe-a6d0823e0ffd

Catalogue record

Date deposited: 07 Jun 2019 16:30
Last modified: 07 Jun 2019 16:30

Export record

Altmetrics

Contributors

Author: Nima Aliakbarinodehi
Author: Francesca Stradolini
Author: Sattar Akbari Nakhjavani
Author: Irene Taurino
Author: Giovanni De Micheli
Author: Sandro Carrara

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×