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Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper

Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper
Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper
Plants are vital for the wellbeing of humankind in a variety of ways. Some plant extracts contain antimicrobial properties that can treat different pathogens. Most of the world's population relies on medicinal plants and natural products for their primary health care needs. Therefore, there is a growing interest in natural products, medicinal plants, and traditional medicine along with a desire to design and develop novel plant-based pharmaceuticals. These plant-based pharmaceuticals may address the concerns of reduced efficacy of synthetic antibiotics due to the emergence of drug-resistant pathogens. In this regard, some plant extracts from black pepper (Piper nigrum) with antimicrobial properties, including piperine, have the potential to be used as natural dietary supplements together with modern therapeutic approaches. This review highlights possible applications of piperine as the active compound in the fields of rational drug design and discovery, pharmaceutical chemistry, and biomedicine. We discuss different extraction methods and pharmacological effects of the analyzed substance to pave the way for further research strategies and perspectives towards the development of novel herbal products for better healthcare solutions.
black pepper, piperine, bio-active compounds, chemical synthesis, extraction, medicinal chemistry, rational drug design, pharmacology
0223-5234
149-161
Shityakov, Sergey
f9d8d8ae-c594-4fcc-a29b-442e0e3e908e
Bigdelian, Ehsan
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Hussein, Aqeel A.
c6645ce9-c288-4b21-8af4-6f481b600bf1
Hussain, Muhammad Bilal
c9ace14f-c570-4e21-8f6b-3c38fda7a8c0
Tripathi, Yogesh Chandra
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Khan, Muhammad Usman
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Shariati, Mohammad Ali
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Shityakov, Sergey
f9d8d8ae-c594-4fcc-a29b-442e0e3e908e
Bigdelian, Ehsan
9b5bc2f1-830b-49b9-a910-8aa88d5c5e3e
Hussein, Aqeel A.
c6645ce9-c288-4b21-8af4-6f481b600bf1
Hussain, Muhammad Bilal
c9ace14f-c570-4e21-8f6b-3c38fda7a8c0
Tripathi, Yogesh Chandra
7b2bc32f-6980-474b-a38f-9263a804e23e
Khan, Muhammad Usman
a43fdb5b-2203-402a-a656-7391cdd26330
Shariati, Mohammad Ali
2e6b011d-26c6-49b9-b4dc-4d3a25f9deb2

Shityakov, Sergey, Bigdelian, Ehsan, Hussein, Aqeel A., Hussain, Muhammad Bilal, Tripathi, Yogesh Chandra, Khan, Muhammad Usman and Shariati, Mohammad Ali (2019) Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper. European Journal of Medicinal Chemistry, 176, 149-161. (doi:10.1016/j.ejmech.2019.04.002).

Record type: Article

Abstract

Plants are vital for the wellbeing of humankind in a variety of ways. Some plant extracts contain antimicrobial properties that can treat different pathogens. Most of the world's population relies on medicinal plants and natural products for their primary health care needs. Therefore, there is a growing interest in natural products, medicinal plants, and traditional medicine along with a desire to design and develop novel plant-based pharmaceuticals. These plant-based pharmaceuticals may address the concerns of reduced efficacy of synthetic antibiotics due to the emergence of drug-resistant pathogens. In this regard, some plant extracts from black pepper (Piper nigrum) with antimicrobial properties, including piperine, have the potential to be used as natural dietary supplements together with modern therapeutic approaches. This review highlights possible applications of piperine as the active compound in the fields of rational drug design and discovery, pharmaceutical chemistry, and biomedicine. We discuss different extraction methods and pharmacological effects of the analyzed substance to pave the way for further research strategies and perspectives towards the development of novel herbal products for better healthcare solutions.

Text
10.1016@j.ejmech.2019.04.002 - Accepted Manuscript
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More information

Accepted/In Press date: 1 April 2019
e-pub ahead of print date: 5 April 2019
Published date: 15 August 2019
Keywords: black pepper, piperine, bio-active compounds, chemical synthesis, extraction, medicinal chemistry, rational drug design, pharmacology

Identifiers

Local EPrints ID: 431659
URI: http://eprints.soton.ac.uk/id/eprint/431659
ISSN: 0223-5234
PURE UUID: 23ce402e-502d-45e7-9a94-e44328ef7087

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Date deposited: 12 Jun 2019 16:30
Last modified: 07 Oct 2020 06:31

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Contributors

Author: Sergey Shityakov
Author: Ehsan Bigdelian
Author: Aqeel A. Hussein
Author: Muhammad Bilal Hussain
Author: Yogesh Chandra Tripathi
Author: Muhammad Usman Khan
Author: Mohammad Ali Shariati

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