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GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI
Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
2375-2548
Alves, Alexessander Couto
e5202536-1ed0-4c51-a211-e1deef3092b6
De Silva, N. Maneka G.
b701601c-ced0-443a-b4ad-4087860dba3f
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Barton, Sheila
4f674382-ca0b-44ad-9670-e71a0b134ef0
Early Growth Genetics (EGG) Consortium
Alves, Alexessander Couto
e5202536-1ed0-4c51-a211-e1deef3092b6
De Silva, N. Maneka G.
b701601c-ced0-443a-b4ad-4087860dba3f
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Barton, Sheila
4f674382-ca0b-44ad-9670-e71a0b134ef0

Alves, Alexessander Couto and De Silva, N. Maneka G. , Early Growth Genetics (EGG) Consortium (2019) GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI. Science Advances, 5 (9). (doi:10.1126/sciadv.aaw3095).

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Abstract

Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

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Accepted/In Press date: 4 June 2019
e-pub ahead of print date: 4 September 2019

Identifiers

Local EPrints ID: 431748
URI: http://eprints.soton.ac.uk/id/eprint/431748
ISSN: 2375-2548
PURE UUID: d0a1230a-d561-41e9-abce-23b1db8c2ba2
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Sheila Barton: ORCID iD orcid.org/0000-0003-4963-4242

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Date deposited: 14 Jun 2019 16:30
Last modified: 26 Nov 2021 02:45

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Contributors

Author: Alexessander Couto Alves
Author: N. Maneka G. De Silva
Author: Hazel Inskip ORCID iD
Author: Sheila Barton ORCID iD
Corporate Author: Early Growth Genetics (EGG) Consortium

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